Skip to main content

Table 5 Factors associated with ACT therapeutic ineffectiveness reporting in the past 6 months among 685 healthcare professionals, Uganda, 2018

From: Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting

Variable

Reported ACT therapeutic ineffectiveness

Crude analysis

Adjusted analysis

Yes, n (%)

No, n (%)

OR

95% CI

p-value

aOR

95% CI

p-value

Health facility status

 Other

52 (16)

279 (84)

1.0

  

1.0

  

 Hospital

85 (24)

269 (76)

1.7

1.16–2.49

0.007

2.4

1.41–4.21

0.001

Sector of practice

 Public

54 (20)

222 (80)

1.0

  

1.0

  

 Private

83 (20)

326 (80)

1.0

0.71–1.53

0.815

1.5

0.85–2.60

0.168

Region

 Central

67 (23)

228 (77)

1.0

  

1.0

  

 Eastern

38 (30)

90 (70)

1.4

0.90–2.29

0.128

1.0

0.57–1.66

0.907

 Northern

22 (17)

110 (83)

0.7

0.40–1.16

0.157

0.5

0.28–0.93

0.029

 Western

10 (8)

120 (92)

0.3

0.14–0.57

<0.001

0.4

0.17–0.77

0.008

Professional cadre

 Non-nurse

58 (17)

293 (83)

1.0

  

1.0

  

 Nurse

79 (24)

255 (76)

1.6

1.07–2.28

0.020

1.4

0.91–2.28

0.119

Gender

 Female

80 (24)

256 (76)

1.0

  

1.0

  

 Male

57 (16)

292 (84)

0.6

0.43–0.91

0.015

0.7

0.46–1.16

0.108

Age

 ≥ 25 years

107 (19)

466 (81)

1.0

  

1.0

  

 < 25 years

30 (27)

82 (73)

1.6

1.00–2.54

0.051

2.2

1.29–3.76

0.004

Suspected ACT therapeutic ineffectiveness in past 4 weeks 

 No

54 (12)

405 (88)

1.0

  

1.0

  

 Yes

83 (37)

143 (63)

4.4

2.94–6.44

<0.001

2.3

1.29–3.92

0.004

Patient complaint of ACT therapeutic ineffectiveness in past 4 weeks

 No

39 (10)

361 (90)

1.0

  

1.0

  

 Yes

98 (34)

187 (66)

4.9

3.22–7.32

<0.001

2.9

1.62–5.12

< 0.001

  1. ACT: Artemisinin-based combination therapy