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Table 1 Effect of topical application of Tenebenalâ„¢ and two standard comparators on adult female Anopheles gambiae

From: Tenebenal: a meta-diamide with potential for use as a novel mode of action insecticide for public health

Strain

Insecticide

Concentration

30 min

24 h

48 h

72 h

KD (%)

Breakpoint (%)

Mortality (%)

Breakpoint (%)

Mortality (%)

Breakpoint (%)

Mortality (%)

Breakpoint (%)

Kisumu

Tenebenalâ„¢

0.00000625%

100.0

 < 0.00000625

66.7

0.000025

60.0

0.00000125

63.3

0.00000125

0.00000125%

88.0

73.3

80.0

80.0

0.000025%

88.4

83.9

96.8

100.0

0.00005%

100.0

96.7

100.0

100.0

0.0001%

91.7

96.6

96.6

96.6

Etofenprox

0.0001%

87.1

 < 0.0001

50.0

0.001

53.6

0.001

53.6

0.001

0.001%

95.9

82.8

89.7

86.2

0.01%

96.0

93.3

96.7

96.7

0.10%

100.0

100.0

100.0

100.0

1%

100.0

100.0

96.7

96.7

Deltamethrin

0.0001%

100.0

 < 0.0001

100.0

 < 0.0001

100.0

 < 0.0001

100.0

 < 0.0001

0.001%

100.0

100.0

100.0

100.0

0.01%

100.0

100.0

100.0

100.0

0.10%

100.0

100.0

96.6

100.0

1%

100.0

100.0

100.0

100.0

Tiassalé 2

Tenebenalâ„¢

0.00000625%

6.7

 > 0.0001

96.7

 < 0.00000625

96.7

 < 0.00000625

96.7

 < 0.00000625

0.00000125%

36.7

96.7

100.0

100.0

0.000025%

17.4

90.0

96.7

96.7

0.00005%

18.5

97.0

100.0

100.0

0.0001%

23.3

86.7

100.0

100.0

Etofenprox

0.0001%

11.1

1

14.4

1

14.4

0.1

14.4

0.1

0.001%

56.7

13.3

26.7

23.3

0.01%

71.9

51.9

62.2

58.5

0.1%

66.7

70.0

80.0

80.0

1%

89.3

92.6

92.6

92.6

Deltamethrin

0.0001%

65.9

0.001

13.7

0.1

16.7

0.01

20.0

0.01

0.001%

85.6

57.4

46.7

46.7

0.01%

74.1

74.1

85.2

96.3

0.1%

90.0

100.0

100.0

100.0

1%

96.7

100.0

100.0

100.0

  1. Efficacy was tested against Kisumu (insecticide susceptible) and Tiassalé 2 (resistant) strains. KD and mortality was observed 30 min and 24, 48 and 72 h after topical application, respectively, and were corrected for negative control mortality using Abbott’s formula where mortality was greater than 5%. The breakpoint at each observation point denotes the lowest concentration at which the 80% mortality threshold, the measure of efficacy given by WHO for IRS formulations, was reached