Skip to main content

Table 2 Effect of exposure to Tenebenalâ„¢ applied to a filter paper in a WHO tube bioassay on adult female mosquitoes

From: Tenebenal: a meta-diamide with potential for use as a novel mode of action insecticide for public health

Strain

Concentration (%)

% Knock down or Mortality

Breakpoint 24 h

Breakpoint 48 h

Breakpoint 72 h

1 h

24 h

48 h

72 h

   

Kisumu

(An. gambiae)

1

0.0

100.0

100.0

100.0

0.001

0.0001

 < 0.00001

0.1

4.0

100.0

100.0

100.0

0.01

0.0

100.0

100.0

100.0

0.001

10.0

100.0

100.0

100.0

0.0001

6.7

76.0

88.0

92.0

0.00001

0.0

39.3

67.9

82.1

Kisumu RDL

(An. gambiae)

1

0.0

100.0

100.0

100.0

0.001

0.001

0.001

0.1

3.2

100.0

100.0

100.0

0.01

0.0

100.0

100.0

100.0

0.001

0.0

100.0

100.0

100.0

0.0001

0.0

65.4

68.9

49.8

0.00001

0.0

0.0

25.0

11.0

Akron

(An. gambiae)

1

5.6

100.0

100.0

100.0

0.001

0.001

0.001

0.1

0.0

100.0

100.0

100.0

0.01

5.6

100.0

100.0

100.0

0.001

0.0

100.0

100.0

100.0

0.0001

0.0

0.0

5.6

16.7

0.00001

10.5

16.7

55.6

61.1

Tiassalé 2

(An. gambiae)

1

0.0

100.0

100.0

100.0

0.001

0.001

0.001

0.1

0.0

100.0

100.0

100.0

0.01

0.0

88.9

91.8

100.0

0.001

0.0

100.0

100.0

100.0

0.0001

0.0

30.0

14.8

20.8

0.00001

2.2

31.3

27.1

29.5

New Orleans

(Ae. aegypti)

1

0.0

100.0

100.0

100.0

0.001

0.001

0.001

0.1

10.0

100.0

100.0

100.0

0.01

0.0

96.7

100.0

100.0

0.001

30.0

100.0

100.0

100.0

0.0001

20.0

26.7

33.3

33.3

0.00001

20.0

33.3

33.3

33.3

Cayman

(Ae. aegypti)

1

0.0

100.0

100.0

100.0

0.01

0.001

0.001

0.1

0.0

100.0

100.0

100.0

0.01

0.0

100.0

100.0

100.0

0.001

0.0

79.3

89.7

96.6

0.0001

0.0

3.6

7.1

14.3

0.00001

0.0

0.0

0.0

3.3

  1. KD and mortality was observed 1, 24, 48 and 72 h after the start of exposure, and is reported as the average of 3 replicates of 10 mosquitoes. Values are corrected for negative control mortality using the Abbott’s formula where mortality in the negative control was greater than 5%. In one replicate of the Tiassalé 2 assay one negative control tube produced 100% mortality; this replicate was excluded from analysis. The breakpoint at each observation point denotes the lowest concentration at which the 80% mortality threshold, the measure of efficacy given by WHO for IRS formulations [17], was reached