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Table 1 Diagnostic performance of vivax malaria and dengue fever flags

From: Performance evaluation of machine learning-based infectious screening flags on the HORIBA Medical Yumizen H550 Haematology Analyzer for vivax malaria and dengue fever

    Overall Febrile Malaria or dengue infected Malaria infected
Nsamples 1422 1341 412 202
Vivax malaria ROC AUC 0.902 [0.880–0.924] 0.902 [0.880–0.924] 0.900 [0.877—0.923] 0.901 [0.868—0.933]
cut-off 0.5 Sensitivity 65.2% [60.2–69.9%] 65.2% [60.2–69.9%] 65.2% [60.2–69.9%] 65.2% [60.2–69.9%]
Specificity 98.9% [98.5–99.3%] 99% [98.5–99.3%] 98.2% [96.6–99.1%] 100% [90.4 – 100%]
PPV 90.2% [86.2–93.2%] 91.3% [87.3–94.0%] 96.8% [93.8–98.4%] 100% [ -]
NPV 95% [94.3–95.6%] 94.7% [94.0–95.4%] 77.8% [75.3–80.1%] 22% [19.6–24.4%]
Younden 0.642 0.642 0.635 0.652
cut-off 0.31 Sensitivity 72.0% [67.2–76.4%] 72.0% [67.2–76.4%] 72.0% [67.2–76.4%] 72.0% [67.2–76.4%]
Specificity 97.9% [97.3–98.4%] 98% [97.4–98.5%] 96.9% [94.9–98.2%] 100% [90.4 – 100%]
PPV 83.9% [79.7–87.3%] 85.2% [81.1–88.5%] 95.0% [91.8–97.0%] 100% [ -]
NPV 95.9% [95.2–96.5%] 95.6% [94.9–96.3%] 81.1% [78.4–83.5%] 25.9% [22.9–29.2%]
Younden 0.699 0.700 0.689 0.720
Dengue ROC AUC 0.814 [0.793–0.834] 0.808 [0.787–0.829] 0.904 [0.883–0.926] -
cut-off 0.5 Sensitivity 79.3% [75.2–82.9%] 80.0% [75.9–83.5%] 79.3% [75.2–82.9%] -
Specificity 71.6% [69.8–73.3%] 70.1% [68.1–71.9%] 86.4% [82.7–89.5%] -
PPV 33.0% [31.3–34.8%] 33.2% [31.5–35.0%] 86.2% [82.9–89.0%] -
NPV 95.2% [94.2–96.0%] 95.0% [93.9–95.8%] 79.6% [76.4–82.5%] -
Younden 0.509 0.501 0.658 -