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Fig. 3 | Malaria Journal

Fig. 3

From: Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study

Fig. 3

a PROMALS3D MSA results showing the conservation of all structural and functional residues. A violet color shows conserved residues in all aligned sequences whereas residues conserved in only PTKTs are indicated in red and their corresponding variations in HsTKT in black. Distinct insertions in PTKTs are labelled as insertion I and II. All key residues are shown with an asterisk. b Detailed sequence logo representation of TPP and TKT motifs. c All versus all pairwise sequence identity calculations. d Phylogenetic tree derived using MSA from PROMALS3D. Maximum Likelihood method based on the Le_Gascuel_2008 model [28] was used for tree calculations at 90% gap deletions applying the Neighbor-Join and BioNJ algorithms. The tree with the highest log likelihood (− 11,888.05) is shown. Evolutionary relationships are shown in dashed boxes. Red; cluster of PTKTs. Cluster I and II indicate HI and RI Plasmodium sp. respectively. Blue; HsTKT cluster with Anopheles darlingi TKT

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