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Table 1 Clinical and laboratorial characteristics of Pv/HIV Co hospitalized patients at FMT-HVD

From: Should we care about Plasmodium vivax and HIV co-infection? A systematic review and a cases series from the Brazilian Amazon

ID

Sex/age

Viral load (copies/mL)

CD4 + cell count (cells/μL)

First malaria episode/semiquantitative Parasitemia (+)c

Concomitant conditions/co-morbidities

AIDS defining illness

ARV treatment/adherence

Severe malaria (WHO criteria)

1

F, 22

19,109

130

Yes/+ + 

Pregnancy (22 weeks)

No

No

No

2

M, 51

0

1202

No/+ +

None

No

No

No

3

F, 27

ND

6b

No/+

OC, TB (5th month treatment)

Yes

3Tc + AZT + ATV/r

Low adherence.

No

4

M, 52

ND

ND

Yes/+ + 

None

No

3Tc + AZT + LPV/r.

Low adherence

No

5

F, 24

1,740

536

No/+ + 

G6PDd

No

No

Significant bleeding (persistent brownish metrorrhagia) and respiratory distress

6

M, 14

162

325

Yes/+ + 

None

No

AZT + 3Tc + LPV/r + RAL/

Low adherence.

No

7

M, 42

ND

ND

No/+ + 

TB (2nd month treatment), NTX, SYP

Yes

TDF + 3Tc + EFV/

Low adherence

No

8

M, 27

58,825

17

No/+ + 

TB, NTX, PNM, OC

Yes

AZT + 3Tc + LPV/r/

Low adherence.

No

9

M, 31

21,271

126

Yes/+ + 

None

No

3Tc + AZT + EFV/yes

No

10

M, 29

90,336b

23b

No/+ + + 

AIDS wasting syndrome, GTB, SYP

Yes

No

Anemia (6.7 g/dL), pulmonary edema and respiratory distress

11

M, 66

0

542

No/1/2+

None

No

3Tc + AZT + RTV/

Low adherence.

No

12

M, 26

14,763

228

Yes/+ + 

TB (2nd month treatment)

No

3Tc + AZT + EFV/

Started treatment at hospital.

No

13

M, 29

6894

266

Yes/+ + + 

Asthma

No

3Tc + AZT + LPV/r/

Low adherence.

No

14

F, 31

660

308

No/+ + 

G6PDd

No

3Tc + ATV + TDF/

Yes

Hyperbilirubinemia (total bilirubin = 12.09 mg/dL) + AST (81 IU/L); ALT (105 IU/L), GGT (108 IU/L), LDH (609 IU/L)

15

F, 19

88,561b

195b

Yes/+ 

NTX

Yes

No

No

16

F, 49

56b

188b

Yes/+ 

Hypertension, DM, Obesity, HCV, HerZ, AKI

Yes

3Tc + TDF + DTG/ Yes

No

17

M, 13

230

417

Yes/1/2 + 

None

No

3Tc + AZT + LPV/r

Low adherence.

No

18

M, 51

NDa

NDa

No/+ + 

NTX

Yes

AZT + 3TC + LPV/r

Low adherence.

No

19

M, 50

262,604

427

No/+ 

TB, AKI, DM, LLC, ISSO, SAL

Yes

No

Respiratory distress

20

M, 39

0b

145b

Yes/+ + + 

None

No

AZT + 3TC + LPV/r

Low adherence.

No

21

F, 35

NDa

NDa

Yes/+ + 

TB, HIV associated wasting syndrome

Yes

HIV status unknown until hospitalization. No treatment.

Hyperbilirubinemia (5.71 mg/dL) + AST (558 IU/L) and GGT (441 IU/L) associated to other organ dysfunction, AKI (creatinine 4.5 mg/dL), metabolic acidosis and respiratory distress

  1. M male, F female, DM diabetes mellitus, TB tuberculosis, ISSO isosporiasis, SAL Salmonella, NTX neurotoxoplasmosis, CMV cytomegalovirus, ASC Ascaris lumbricoides, GIA Giardia spp., SAL Salmonella spp., SYP Syphilis, PNM pneumonia, OC oropharyngeal infection by Candida spp., LLC lower limb cellulitis, GTB ganglionar tuberculosis, PFP peripheral facial nerve paralysis, BC Bowen’s disease, HCV hepatitis C virus, HerZ Herpes zoster virus, HSV Herpes simplex virus, AKI acute kidney insufficiency, G6PDd glucose-6 phosphate dehydrogenase enzyme deficiency, 3Tc lamivudine, AZT zidovudine/azidothymidine, ATV/r atazanavir/ritonavir, TDF tenofovir, EFV efavirenz, DTG dolutegravir, LPV/r lopinavir/ritonavir, RAL raltegravir, ND not defined
  2. aRDT positive at hospital admission
  3. bAt hospital admission
  4. c1/2 + (200–300 parasites/mm3);  + (301–500 parasites/mm3); +  + (501–10,000 parasites/mm3); +  +  + (10,001– 100,000 parasites/mm3); and +  +  +  + (> 100,001 parasites/mm3)