Should we care about Plasmodium vivax and HIV co-infection? A systematic review and a cases series from the Brazilian Amazon

Table 3 HIV-Plasmodium vivax co-infection case reports

Author, year	Sex/age	Viral load (copies/mL)	CD4 + cell count (cells/μL)	Primoinfection/semiquantitative parasitemia (+)	Concomitant conditions/co-morbidities	AIDS defining illness	ARV treatment/adherence	Severe malaria (WHO criteria)
Katongole-Mbidde, 1988 [36]	F, 37	ND^a	ND^a	ND/ND	PNM (Pneumocystis jirovecii)	Yes	ND	No
McIver, 2010 [37]	M, 57	0	500	ND/+ + +	PNM	Yes	3TC + AZT + ATV/yes	No
Tano, 2014 [84]	M, 50	2352	115	No/patient was diagnosed by IFI	ND	No	ND/No	Anemia (5.6 g/dL)
Ranaweera, 2018 [38]	M, 36	ND	ND	No/+ + + ^b	TB/PNM (Pneumocystis jirovecii)	Yes	ND	Hyperbilirubinemia (total bilirubin = 5.03), Shock (Systolic BP < 80 mmHg)
Montenegro-Idrogo, 2019 [39]	F, 35	105,000^b	350^b	Yes/+ +	ND	No	No	Impaired consciousness (Glascow coma score 6/15)
Montenegro-Idrogo, 2019 [39]	M, 43	ND	ND	Yes/+ ^b	ND	No	No	No

M male, F female, BP blood pressure, TB tuberculosis, PNM pneumonia, 3Tc lamivudine, IFI indirect immunofluorescence, AZT zidovudine/azidothymidine, ATV atazanavir, TDF tenofovir, ND not defined
^aRDT positive at hospital admission
^bAt hospital admission

ISSN: 1475-2875