Fig. 3

Fluctuation of non-synonymous mutations in the Northern Amazon Basin between 2006 and 2015. The graphic shows the dynamics of the 976F and 1076L polymorphisms and the number of reported cases in the Northern Amazon Basin. The “y” axis on the left shows the number of reported cases for the barplot. The “y” axis on the right depicts the percentage of the 976F and 1076L mutations for the lineplot whereas the “x” axis indicate the years. (1) Global fund’s Malaria project “PAMAFRO” (2005–2010). Plasmodium vivax data from 2010 was not included in the graphic because of the low sample size for that year (n = 3)