Infant sex modifies associations between placental malaria and risk of malaria in infancy

Malaria Journal

Table 5 Effect of IPTp on malaria incidence in infants that is mediated by preventing placental malaria

Infant category	Total effect		Direct effect		Mediated effect		% of mediated effect^a
Infant category	IRR (95% CI)	p-value	IRR (95% CI)	p-value	IRR (95% CI)	p-value	% of mediated effect^a
All sexes	0.89 (0.75–1.04)	0.16	0.94 (0.73–1.17)	0.58	0.95 (0.77–1.16)	0.61	43.5%
Male	0.77 (0.61–0.99)	0.05	0.97 (0.67–1.36)	0.89	0.79 (0.56–1.09)	0.17	89.7%
Females	1.01 (0.81–1.26)	0.96	0.92 (0.71–1.22)	0.56	1.09 (0.87–1.38)	0.45	–

CI confidence intervals, IRR incidence rate ratio
IRRs represent the effect of IPTp DP versus SP on the incidence of malaria in infants. Confidence intervals reported here were obtained by bootstrapping and may differ from those reported in the primary analysis which used the delta method specifying robust standard errors
^aProportion of mediated effect was calculated using [ln(IRR_{mediated effect})/ln(IRR_{total effect})]*100

ISSN: 1475-2875