Table 2 Performance of the diagnostic tests with reference to each other
PCR as reference | Microscopy as reference | RDT as reference | ||||
|---|---|---|---|---|---|---|
Parameters | Microscopy % (95%CI) | RDTs % (95%CI) | PCR % (95%CI) | RDT % (95%CI) | PCR % (95%CI) | Microscopy % (95%CI) |
Sensitivity | 33.3 (14.6–57) | 52.4 (29.8–74.3) | 87.5 (47.3–99.7) | 62.5 (24.5–91.5) | 31.4 (16.9–49.3) | 14.3 (4.81–30.3) |
Specificity | 99.9 (99.2–100) | 96.5 (94.8–97.7) | 98(96.6–98.9) | 95.7(93.9–97.1) | 98.5(97.3–99.3) | 99.6 (98.7–99.9) |
PPV | 87.5( 47.3–99.7) | 31.4(16.9–49.3) | 33.33 (14.6–57) | 14.3 (4.81–30.3) | 52.4(29.8–74.3) | 62.5(24.5–91.5) |
NPV | 98 (96.6–98.9) | 98.5(97.3–99.3) | 99.2(99.2–100) | 99.6(98.7–99.9) | 96.5(94.8–97.7) | 95.7(93.9–97.1) |
ROC area | 0.666 (0.563–0.769) | 0.744(0.635–0.854) | 0.927(0.805–1) | 0.791 (0.611–0.97) | 0.65 (0.571–0.728) | 0.569 (0.51–0.628) |
Percentage agreement of the tests | 97.86% | 95.16% | 97.86% | 95.30% | 95.16% | 95.30% |
Cohan Kappa value | 0.4741 | 0.3693 | 0.4741 | 0.2181 | 0.3693 | 0.2181 |
Kappa p-value | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |