Skip to main content

Table 1 Changes in the frequency of Pfcrt and Pfmdr1 genotypes between 1998 and 2020

From: Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Gene Mutation Allele 1998–2004 (%, n/N) 2005–2010 (%, n/N) 2011–2016 (%, n/N)  ≥ 2017 (%, n/N) P-value
Pfcrt K76T K76 20.1 (72/359) 37.9 (288/760) 32.5 (433/1331) 57.0 (546/958) P < 0.0001*
76 T 79.9 (287/359) 62.1 (472/760) 67.5 (898/1331) 43.0 (412/958)
Pfmdr1 N86Y N86 17.3 (57/330) 41.9 (317/756) 9.4 (40/426) 69.5 (401/577) P < 0.0001*
86Y 82.7 (273/330) 58.1 (439/756) 90.6 (386/426) 30.5 (176/577)
  1. *P < 0.05: Statistically significant, N: number of amino acid substitutions, N: Total number of samples genotyped