|
Gene
|
Mutation
|
Allele
|
1998–2004 (%, n/N)
|
2005–2010 (%, n/N)
|
2011–2016 (%, n/N)
|
≥ 2017 (%, n/N)
|
P-value
|
|---|
|
Pfcrt
|
K76T
|
K76
|
20.1 (72/359)
|
37.9 (288/760)
|
32.5 (433/1331)
|
57.0 (546/958)
|
P < 0.0001*
|
|
76 T
|
79.9 (287/359)
|
62.1 (472/760)
|
67.5 (898/1331)
|
43.0 (412/958)
|
|
Pfmdr1
|
N86Y
|
N86
|
17.3 (57/330)
|
41.9 (317/756)
|
9.4 (40/426)
|
69.5 (401/577)
|
P < 0.0001*
|
|
86Y
|
82.7 (273/330)
|
58.1 (439/756)
|
90.6 (386/426)
|
30.5 (176/577)
|
- *P < 0.05: Statistically significant, N: number of amino acid substitutions, N: Total number of samples genotyped
