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Table 1 Changes in the frequency of Pfcrt and Pfmdr1 genotypes between 1998 and 2020

From: Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Gene

Mutation

Allele

1998–2004 (%, n/N)

2005–2010 (%, n/N)

2011–2016 (%, n/N)

 ≥ 2017 (%, n/N)

P-value

Pfcrt

K76T

K76

20.1 (72/359)

37.9 (288/760)

32.5 (433/1331)

57.0 (546/958)

P < 0.0001*

76 T

79.9 (287/359)

62.1 (472/760)

67.5 (898/1331)

43.0 (412/958)

Pfmdr1

N86Y

N86

17.3 (57/330)

41.9 (317/756)

9.4 (40/426)

69.5 (401/577)

P < 0.0001*

86Y

82.7 (273/330)

58.1 (439/756)

90.6 (386/426)

30.5 (176/577)

  1. *P < 0.05: Statistically significant, N: number of amino acid substitutions, N: Total number of samples genotyped