Gene | Mutation | Allele | 1998–2004 (%, n/N) | 2005–2010 (%, n/N) | 2011–2016 (%, n/N) | ≥ 2017 (%, n/N) | P-value |
---|---|---|---|---|---|---|---|
Pfcrt | K76T | K76 | 20.1 (72/359) | 37.9 (288/760) | 32.5 (433/1331) | 57.0 (546/958) | P < 0.0001* |
76 T | 79.9 (287/359) | 62.1 (472/760) | 67.5 (898/1331) | 43.0 (412/958) | |||
Pfmdr1 | N86Y | N86 | 17.3 (57/330) | 41.9 (317/756) | 9.4 (40/426) | 69.5 (401/577) | P < 0.0001* |
86Y | 82.7 (273/330) | 58.1 (439/756) | 90.6 (386/426) | 30.5 (176/577) |