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Table 2 Changes in the frequency of Pfcrt haplotypes between 1998 and 2020

From: Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Gene Haplotype 1998–2004
(%, n/N)
2005–2010
(%, n/N)
2011–2016
(%, n/N)
 ≥ 2017
(%, n/N)
P-value
Pfcrt CVMNK 7.7 (12/156) 20.0 (1/5) 56.1 (101/180) 40.2 (323/804) P < 0.0001
Pfcrt CVIET 57.1 (89/156) 0.0 (0/5) 36.7 (66/180) 57.9 (301/520) P < 0.0001
  1. *P < 0.05: Statistically significant, n: Number of amino acid substitutions, N: Total number of samples genotyped