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Table 4 Changes in the frequency of Pfdhfr and Pfdhps haplotypes between 1998 and 2020

From: Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Gene Haplotype 1998–2008
(%, n/N)
2009–2020
(%, n/N)
P-value
Pfdhfr IRN 66.2 (1,821/2,751) 67.3 (1,295/1,924) P = 0.427
Pfdhfr-Pfdhps IRNG 47.5 (207/436) 28.7 (141/492) P < 0.0001
Pfdhfr-Pfdhps IRNGE 0.0 (0/81) 0.3 (5/1,681) P = 0.623
  1. *P < 0.05: Statistically significant, n: Number of amino acid substitutions, N: Total number of samples genotyped