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Table 4 Changes in the frequency of Pfdhfr and Pfdhps haplotypes between 1998 and 2020

From: Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Gene

Haplotype

1998–2008

(%, n/N)

2009–2020

(%, n/N)

P-value

Pfdhfr

IRN

66.2 (1,821/2,751)

67.3 (1,295/1,924)

P = 0.427

Pfdhfr-Pfdhps

IRNG

47.5 (207/436)

28.7 (141/492)

P < 0.0001

Pfdhfr-Pfdhps

IRNGE

0.0 (0/81)

0.3 (5/1,681)

P = 0.623

  1. *P < 0.05: Statistically significant, n: Number of amino acid substitutions, N: Total number of samples genotyped
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Malaria Journal

ISSN: 1475-2875

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