Skip to main content

Table 1 Characteristics of children with severe malaria based on age at first cognitive assessment

From: Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria

 

Children < 5 years (n = 295)

Children ≥ 5 years of age (n = 89)

Admission characteristics

 Age (years), mean (SD)

2.9 (0.9)

6.5 (1.6)

 Gender (male), n (%)

172 (58.3)

60 (67.4)

 Weight-for-age z-score, mean (SD)

− 1.2 (1.1)

− 1.1 (1.0)

 Height-for-age z-score, mean (SD)

− 1.3 (1.5)

− 0.8 (1.2)

 Socio-economic status, mean (SD)

9.1 (3.0)

10.1 (3.2)

 HOME z-score, mean (SD)

− 0.08 (1.04)

− 0.08 (0.88)

Maternal education, n (%)

 Primary 6 or lower

114 (38.6)

29 (32.6)

 Primary 7

63 (21.4)

20 (22.5)

 Secondary or higher

109 (37.0)

36 (40.5)

 Unknown

9 (3.1)

4 (4.5)

Paternal education, n (%)

 Primary 6 or lower

62 (21.0)

10 (11.2)

 Primary 7

44 (14.9)

18 (20.2)

 Secondary or higher

133 (45.1)

41 (46.1)

 Unknown

56 (19.0)

20 (22.5)

HIV infected, n (%)

6 (2.1)

3 (3.4)

Sickle cell status, n (%)

 HbAA

286 (97.3)

78 (87.6)

 HbAS

2 (0.7)

1 (1.1)

 HbSS

6 (2.0)

10 (11.2)

Admission severe malaria criteria

 Cerebral malaria, n (%)

145 (49.2)

52 (58.4)

 Deep breathing, n (%)

19 (6.4)

2 (2.3)

 Repeated convulsions, n (%)

102 (34.6)

27 (30.3)

 Prostration, n (%)

215 (72.9)

63 (70.8)

 Shock, n (%)

–

–

 Bleeding, n (%)

2 (0.7)

1 (1.1)

 Jaundice, n (%)

197 (66.8)

51 (57.3)

 Severe malarial anaemia, n (%)

187 (63.4)

40 (44.9)

 Hypoglycaemia on admission, n (%)

19 (6.6)

1 (1.2)

 Lactic acidosis, n (%)

117 (42.2)

19 (24.1)

 Acute kidney injury, n (%)

102 (34.6)

28 (31.5)

 Hyperparasitaemia, n (%)

54 (19.0)

12 (13.6)

 Number of SM criteria present, mean (SD)

3.9 (1.6)

3.3 (1.2)

Neurocognitive follow-up visits, n tested

Children < 5 years

Children ≥ 5 years

One week post-discharge, n tested

257

86

Six months follow-up, n tested

253

98

12 months follow-up, n tested

225

129

24 months follow-up, n tested

148

209

Total for any follow-up visits, n tested

295

218

Admission Angpt-2 (median, IQR), ng/mL

1.78 (0.99, 3.13)

1.65 (0.84, 3.06)

  1. Data presented as mean (standard deviation), or n (%) unless otherwise indicated