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Table 3 Anti-malarial activity of the 80% rhizome extract of Kniphofia folosia in mice infected with Plasmodium berghei

From: In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents

Test substances

Dose (mg/kg/day)

Percent parasitaemia

Percent suppression

Mean survival time (in days)

Vehicle1

0.2 ml

35.9860 ± 1.22034

0.0000

6.0000 ± 0.31623

KF100

100 mg

24.2100 ± 1.18037

32.7200a*c**d*e*

9.4000 ± 0.50990a**e*

KF200

200 mg

17.4920 ± 0.67964

51.3900a*b**e*

9.6000 ± 0.92736a*e*

KF400

400 mg

13.8480 ± 0.76024

61.5200a*b*e*

8.4000 ± 0.24495e*

Chloroquine

25 mg

0.0140 ± 0.00600

99.8000a*

27.2000 ± 0.58310a*b*c*d*

  1. Values are presented as mean ± SEM; n = 5; acompared to vehicle1 (distilled water), bcompared to KF100, ccompared to KF200, dcompared to KF400, ecompared to chloroquine; * (p < 0.001); **(p < 0.01); KF = 80% extracts of K. folosia, numbers refer to doses in mg/kg/day
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Malaria Journal

ISSN: 1475-2875

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