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Table 4 Anti-malarial activity of knipholone and dianellin in mice infected with Plasmodium berghei

From: In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents

Test substances

Dose (mg/kg/day)

Percent parasitaemia

Percent suppression

Mean survival time (in days)

Vehicle3 Knipholone

0.2 ml

46.3560 ± 1.46925

0.0000

6.4000 ± 0.50990

25 mg

30.5440 ± 1.45634

34.1200a*d*e*h*i*

8.8000 ± 0.37417i*

50 mg

26.2640 ± 1.80001

42.6400a*e**h*i*

9.0000 ± 0.54772i*

100 mg

20.7940 ± 0.91475

55.1400a*b*e**f*g*i*

9.2000 ± 0.73485a***i*

200 mg

18.4680 ± 0.97391

60.1600a*b*c**f*g*i*

9.4000 ± 0.24495a**i*

Dianellin

25 mg

32.5280 ± 0.96771

29.8300a*c*d*e*h*h*i*

7.6000 ± 0.24495i*

50 mg

25.9408 ± 0.77243

44.0400a*d*e*g*h*i*

8.2000 ± 0.37417i*

100 mg

21.4303 ± 0.84156

53.7700a*b*c*f*g*i*

8.2000 ± 0.37417i*

Chloroquine

25 mg

0.0140 ± 0.00600

9.8000a‒h*

27.4000 ± 0.400000a‒h*

  1. Values are presented as mean ± SEM; n = 5; acompared to vehicle3 (distilled water), bcompared to knipholone 25 mg, ccompared to knipholone 50 mg, dcompared to knipholone 100 mg, ecompared to knipholone 200 mg, fcompared to dianellin 25 mg, gcompared to dianellin 50 mg, hcompared to dianellin 100 mg, icompared to chloroquine; * (p < 0.001); **(p < 0.01); ***(p < 0.05); numbers refer to doses in mg/kg/day