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Table 3 Comparison of SBP-1 parasite density between DP and SP-AQ arms

From: Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians

Visit

Median density (per μL) [IQR]

Difference in log10 SBP-1 Density

SP-AQ

DP

DP:SP-AQ

MD [95% CI]1

DP:SP-AQ

% Difference [95% CI]2

p-value

Day 0

891.3 [8.2, 2065.4]

330.4 [6.5, 1990.7]

0.01 [− 1.0, 1.0]

3 [− 91, 1019]

0.98

Day 1

21.2 [0.6, 212]

0.6 [0, 2.3]

− 1.5 [− 2.0, − 0.9]

− 97 [− 99, − 89]

< 0.001

Day 2

0.6 [0, 11.2]

0.02 [0, 0.3]

− 1.2 [− 1.8, − 0.6]

− 94 [− 98, 76]

< 0.001

Day 7

0 [0, 0.003]

0 [0, 0.07]

0.09 [− 0.4, 0.6]

24 [− 64, 320]

0.73

Day 14

0 [0, 0]

0 [0, 0]

− 0.3 [− 0.8, 0.3]

− 44 [− 84, 96]

0.36

Day 28

0 [0, 0]

0 [0, 0]

− 0.4 [− 0.8, 0.08]

− 57 [− 85, 19]

0.10

Day 42

0.03 [0, 7.1]

0 [0, 0]

− 1.2 [− 2.1, − 0.3]

− 94 [− 99, − 46]

0.012

  1. IQR interquartile range
  2. 1 Coefficient from linear regression modelling log10 SBP-1 parasite density. Models comparing parasite density at non-baseline visits adjusted for baseline SBP-1 values. A value of 0.001 was added to all values to account for zeroes
  3. 2 Calculated by 100 * (10MD − 1)