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Table 2 Associations between RBC variants and malaria incidence

From: Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

Age groupRed cell variantsVariantMalaria episodesPerson years of follow-upIncidence of malaria PPYUnadjustedAdjusted*
IRR (95% CI)p-valueIRR (95% CI)p-value
ChildrenHaemoglobin variantAA461227621.67ReferenceReference
AS8186201.320.77 (0.64–0.94)0.0090.78 (0.66–0.92)0.003
SS313.40.220.16 (0.03–0.78)0.020.17 (0.04–0.71)0.02
Alpha thalassaemia variantNormal323320611.57ReferenceReference
α−/αα176911061.601.00 (0.85–1.18)0.981.04 (0.91–1.20)0.56
α−/−α2511501.670.97 (0.68–1.38)0.881.19 (0.87–1.62)0.27
G6PD genotypeNormal (male)268015971.68ReferenceReference
Hemizygotes3741702.201.18 (0.85–1.63)0.330.93 (0.71–1.22)0.61
Normal (female)176812241.44ReferenceReference
Heterozygotes4843551.360.91 (0.70–1.18)0.460.80 (0.63–1.01)0.06
Homozygotes7240.51.781.21 (0.60–2.44)0.590.89 (0.51–1.57)0.70
AdultsHaemoglobin variantAA3009360.32ReferenceReference
AS692520.270.85 (0.56–1.30)0.460.99 (0.66–1.49)0.98
Alpha thalassaemia variantNormal2527830.32ReferenceReference
α−/αα1023180.321.01 (0.68–1.48)0.981.10 (0.76–1.59)0.63
α−/−α1170.00.160.50 (0.22–1.15)0.100.58 (0.25–1.33)0.20
G6PD genotypeNormal (male)1355.10.23ReferenceReference
Hemizygotes319.40.160.66 (0.15–2.90)0.580.98 (0.16–5.85)0.98
Normal (female)2949950.30ReferenceReference
Heterozygotes731910.381.26 (0.81–1.97)0.311.13 (0.74–1.72)0.58
Homozygotes111.20.090.39 (0.03–4.41)0.450.40 (0.04–3.92)0.43
  1. * Adjusted for age, average household EIR, and study site