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Table 4 Associations between red cell variants and parasite densities (anti-parasite immunity) in parasitaemic children

From: Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

Red cell variantsVariantUnadjustedAdjusted*
Change in log10 parasite density (95% CI)p-valueChange in log10 parasite density (95% CI)p-value
Haemoglobin variantAAReferenceReference
AS− 0.25 (− 0.37, − 0.12)< 0.001− 0.18 (− 0.29, − 0.07)0.001
SS− 0.4 (− 1.33, 0.53)0.40− 0.11 (− 0.95, 0.73)0.80
Alpha thalassaemia variantNormalReferenceReference
α−/αα− 0.20 (− 0.30, − 0.10)< 0.001− 0.06 (− 0.14, 0.03)0.19
α−/−α0.09 (− 0.14, 0.31)0.450.04 (− 0.15, 0.22)0.71
G6PD genotypeNormal (male)ReferenceReference
Hemizygotes− 0.01 (− 0.22, 0.20)0.92− 0.01 (− 0.18, 0.17)0.94
Normal (female)ReferenceReference
Heterozygotes− 0.18 (− 0.34, − 0.01)0.04− 0.05 (− 0.19, 0.09)0.51
Homozygotes0.05 (− 0.34, 0.44)0.800.12 (− 0.21, 0.45)0.46
  1. * Adjusted for age, average household EIR, and study site