Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

Table 4 Associations between red cell variants and parasite densities (anti-parasite immunity) in parasitaemic children

Red cell variants	Variant	Unadjusted		Adjusted*
Red cell variants	Variant	Change in log¹⁰ parasite density (95% CI)	p-value	Change in log¹⁰ parasite density (95% CI)	p-value
Haemoglobin variant	AA	Reference		Reference
	AS	− 0.25 (− 0.37, − 0.12)	< 0.001	− 0.18 (− 0.29, − 0.07)	0.001
	SS	− 0.4 (− 1.33, 0.53)	0.40	− 0.11 (− 0.95, 0.73)	0.80
Alpha thalassaemia variant	Normal	Reference		Reference
	α−/αα	− 0.20 (− 0.30, − 0.10)	< 0.001	− 0.06 (− 0.14, 0.03)	0.19
	α−/−α	0.09 (− 0.14, 0.31)	0.45	0.04 (− 0.15, 0.22)	0.71
G6PD genotype	Normal (male)	Reference		Reference
	Hemizygotes	− 0.01 (− 0.22, 0.20)	0.92	− 0.01 (− 0.18, 0.17)	0.94
	Normal (female)	Reference		Reference
	Heterozygotes	− 0.18 (− 0.34, − 0.01)	0.04	− 0.05 (− 0.19, 0.09)	0.51
	Homozygotes	0.05 (− 0.34, 0.44)	0.80	0.12 (− 0.21, 0.45)	0.46

ISSN: 1475-2875