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Table 2 Antiplasmodial activity of naphthoquine (NQ) in male and female mice infected with Plasmodium yoelii

From: The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents

Treatment

ED50 (mg/kg)

ED90 (mg/kg)

CQ (male)

0.76 ± 0.16

2.18 ± 0.41

NQ (male)

0.71 ± 0.08

1.10 ± 0.11

NQ (female)

0.94 ± 0.12

1.67 ± 0.47

  1. Chloroquine (CQ) was used as a positive model drug. In vivo experiments consisted of 5 doses, with 9 mice/dose. ED50 and ED90 were calculated by Prism (GraphPad) software from a best-fit curve
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Malaria Journal

ISSN: 1475-2875

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