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Table 4 Metabolic clearance of naphthoquine (NQ) in the liver microsomes of male and female mice, rats, and humans

From: The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents

Speciest1/2 (min)CLint, in vitro (μL/min/mg)
Mice (male)811.3 ± 211.70.90 ± 0.26
Mice (female)436.7 ± 111.21.67 ± 0.47
Rat (male)490.9 ± 180.31.53 ± 0.50
Rat (female)490.0 ± 190.51.57 ± 0.60
Human (male)930.4 ± 200.40.77 ± 0.15
Human (female)1089.0 ± 514.40.80 ± 0.52