Table 4 Metabolic clearance of naphthoquine (NQ) in the liver microsomes of male and female mice, rats, and humans
| Species | t1/2 (min) | CLint, in vitro (μL/min/mg) |
|---|---|---|
| Mice (male) | 811.3 ± 211.7 | 0.90 ± 0.26 |
| Mice (female) | 436.7 ± 111.2 | 1.67 ± 0.47 |
| Rat (male) | 490.9 ± 180.3 | 1.53 ± 0.50 |
| Rat (female) | 490.0 ± 190.5 | 1.57 ± 0.60 |
| Human (male) | 930.4 ± 200.4 | 0.77 ± 0.15 |
| Human (female) | 1089.0 ± 514.4 | 0.80 ± 0.52 |