Safety and feasibility of apheresis to harvest and concentrate parasites from subjects with induced blood stage Plasmodium vivax infection

Table 2 Summary of the main safety findings

	Subject 1	Subject 2	Subject 3	Subject 4	Total AEs
SAEs	0	0	0	0	0
AEs	20	13	15	20	68
AEs related to malaria	13	8	14	19	54
AEs related to apheresis	2	3	0	4	9
Max temp °C	40.2	38.8	40.2	39.6	N/A
Max malaria clinical score	8	1	2	7	N/A
Ibuprofen use	400 mg × 5	400 mg × 5	400 mg × 5	nil	N/A
Acetaminophen use	1 g × 4; 500 mg × 1	1 g × 2	1 g × 4	500 mg × 2; 1 g × 2	N/A
Peak ALT (IU/L)	111	118	47	80	N/A
Peak AST (IU/L)	83	57	42	44	N/A
Platelet Nadir (× 10⁹/L)	119	98	99	75	N/A
Maximum drop in haemoglobin from baseline (g/L)	17	9	25	20	N/A
Lymphocyte Nadir (× 10⁹/L)	0.33	0.43	0.58	0.75	N/A
Peak parasitaemia (parasites/mL)	15,943	35,156	64,243	44,431	N/A

ISSN: 1475-2875