Sulfadoxine-pyrimethamine parasitological efficacy against Plasmodium falciparum among pregnant women and molecular markers of resistance in Zambia: an observational cohort study

Table 2 Estimates of treatment and prophylactic failure of sulphadoxine-pyrimethamine among antenatal care attendees in Nchelenge District, Zambia

Category	Number of women	Proportion of parasite-positive women at day 28, % (n)	95% Confidence intervals
Overall parasitological and prophylactic failure^a	590	18.6 (109)	15.5, 21.8
Total prophylactic failure^b	411	18.3 (75)	14.8, 22.3
Day 0 malaria positives
Day 28 PCR uncorrected parasitological failure	207	30.0 (62)	23.7, 36.2
Day 28 PCR corrected parasitological failure	205^c	15.6 (32)	11.2, 21.3
Day 28 PCR corrected reinfection	60	46.7 (28)	34.2, 59.6
Day 0 malaria negatives
Day 28 PCR uncorrected prophylactic failure	383	12.3 (47)	9.0, 15.6

PCR polymerase chain reaction diagnostic methods
^aAll positives among women who took SP at enrolment and tested malaria positive at day 28 which includes prophylactic and parasitological failures
^bThe total includes aparasitaemic at day 0 and parasitaemic at day 28 plus the 28 women who were parasitaemic at day 0 and day 28 due to reinfection
^cTwo samples could not be differentiated between recrudescence or reinfection, which is reflected in the smaller denominator (205) of samples after PCR correction for parasitological failure

ISSN: 1475-2875