Incremental impact on malaria incidence following indoor residual spraying in a highly endemic area with high standard ITN access in Mozambique: results from a cluster‐randomized study

Chaccour, Carlos; Zulliger, Rose; Wagman, Joe; Casellas, Aina; Nacima, Amilcar; Elobolobo, Eldo; Savaio, Binete; Saifodine, Abuchahama; Fornadel, Christen; Richardson, Jason; Candrinho, Baltazar; Robertson, Molly; Saute, Francisco

doi:10.1186/s12936-021-03611-7

Table 5 Malaria case incidence at health facilities in the overall and under 5 years of age population

From: Incremental impact on malaria incidence following indoor residual spraying in a highly endemic area with high standard ITN access in Mozambique: results from a cluster‐randomized study

Overall population							Under five years
Study	No IRS		IRS		IRR	95%CI	Study	No IRS		IRS		IRR	95%CI
Month	RDT-	RDT +	RDT-	RDT +	IRR	95%CI	Month	RDT-	RDT +	RDT-	RDT +	IRR	95%CI
0	740	807	677	685	0.87	(0.79, 0.97)	0	340	424	315	328	0.83	(0.72, 0.96)
1	1289	2379	1238	1811	0.78	(0.73, 0.83)	1	559	1233	523	889	0.78	(0.71, 0.85)
2	1354	2881	1323	2539	0.9	(0.86, 0.95)	2	501	1390	540	1157	0.9	(0.83, 0.97)
3	1306	2419	1381	2004	0.85	(0.80, 0.90)	3	461	1138	468	877	0.83	(0.76, 0.91)
4	1228	2286	1084	1762	0.79	(0.74, 0.84)	4	396	1098	404	747	0.73	(0.67, 0.81)
5	1353	2577	1252	2195	0.87	(0.83, 0.93)	5	442	1324	450	1023	0.83	(0.77, 0.90)
6	1332	2606	1109	2135	0.84	(0.79, 0.89)	6	450	1306	379	966	0.8	(0.73, 0.87)
7	1367	2246	1230	1785	0.82	(0.77, 0.87)	7	537	1159	487	854	0.79	(0.73, 0.87)
8	1618	2336	1408	1726	0.76	(0.71, 0.81)	8	573	1127	567	790	0.76	(0.69, 0.83)
9	1410	1999	1240	1573	0.81	(0.76, 0.86)	9	568	1019	519	786	0.83	(0.76, 0.91)
10	1449	1898	1342	1562	0.84	(0.79, 0.90)	10	555	987	506	745	0.81	(0.74, 0.90)
11	1384	1441	1196	1043	0.74	(0.69, 0.81)	11	553	673	468	458	0.73	(0.65, 0.83)
12	1306	1644	1130	1115	0.7	(0.64, 0.75)	12	508	744	471	468	0.68	(0.60, 0.76)
13	2485	3455	2014	2365	0.7	(0.67, 0.74)	13	861	1580	705	975	0.66	(0.61, 0.72)
14	2228	3063	1831	2030	0.68	(0.64, 0.72)	14	752	1353	615	784	0.62	(0.57, 0.68)
15	2471	3653	2378	2646	0.74	(0.71, 0.78)	15	808	1764	812	1165	0.71	(0.66, 0.77)
16	2189	3708	2144	2770	0.77	(0.73, 0.81)	16	823	1877	873	1313	0.75	(0.70, 0.81)
17	2111	3986	1840	2999	0.77	(0.74, 0.81)	17	702	1910	610	1289	0.73	(0.68, 0.78)
18	1961	3207	1556	2212	0.71	(0.67, 0.75)	18	668	1597	569	1078	0.73	(0.67, 0.79)
19	1971	2741	1456	1915	0.72	(0.68, 0.76)	19	660	1355	547	921	0.73	(0.67, 0.80)
20	2051	2460	1837	1775	0.74	(0.70, 0.79)	20	697	1206	725	900	0.8	(0.74, 0.88)
21	1891	2487	1696	1961	0.81	(0.76, 0.86)	21	658	1213	663	944	0.84	(0.77, 0.91)
22	1723	1751	1543	1366	0.8	(0.75, 0.86)	22	605	810	554	560	0.74	(0.67, 0.83)
Total	38,217	58,030	33,905	43,974	0.78	(0.77, 0.79)	Total	13,677	28,287	12,770	20,017	0.76	(0.75, 0.78)

IRS: indoor residual spraying, RDT: rapid diagnostic test, IRR: incidence rate ratio. The overall (under 5) population considered in the table was 68,725 (12,670) for IRS and 169,960 (13,427) for non-IRS clusters.

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