Table 2 Geographic distribution of pfcrt and pfmdr1 haplotypes in Plasmodium falciparum isolates returned from Africa
Gene | Haplotypes | Number and prevalence of each haplotype in different region of Africa (n/%) | Â | |||||
|---|---|---|---|---|---|---|---|---|
East Africa | West Africa | Central Africa | South Africa | North Africa | Total | P value | ||
Pfcrt | CVMNK (wild type) | 43 (75.4) | 101 (60.8) | 251 (62.4) | 53 (58.2) | 11 (73.3) | 459 (62.8) | 0.2216 |
CVMNT | 3 (5.3) | 0 | 1 (0.2) | 0 | 0 | 4 (0.55) | 0.01b | |
CVIET | 7 (12.3) | 53 (31.9) | 122 (30.3) | 29 (31.9) | 4 (26.7) | 215 (29.4) | 0.0598 | |
CVMN K/T | 1 (1.8) | 0 | 0 | 0 | 0 | 1 (0.1) | 0.0985b | |
CV M/I N/E K/T | 3 (5.3) | 12 (7.2) | 28(7.0) | 9 (9.9) | 0 | 52 (7.1) | 0.6406 | |
Sub total | Â | 57 | 166 | 402 | 91 | 15 | 731 | Â |
Pfmdr1 | NYD (wild type) | 4 (20.0) | 23 (32.4) | 119 (46.3) | 45 (52.3) | NA | 191 (44.0) | 0.0092 |
YYDa | 0 | 2 (2.8) | 16 (6.2) | 5 (5.8) | NA | 23 (5.3) | 0.6466b | |
NYD | 6 (30.0) | 16 (22.5) | 69 (26.8) | 16 (18.6) | NA | 107 (24.7) | 0.417 | |
NYY | 0 | 0 | 0 | 0 | NA | 0 | NA | |
YFD | 5 (25.0) | 12 (16.9) | 33 (12.8) | 5 (5.8) | NA | 55 (12.7) | 0.0561 | |
YYY | 0 | 1 (1.4) | 0 | 0 | NA | 1 (0.2) | NA | |
NFY | 0 | 0 | 1 (0.4) | 0 | NA | 1 (0.2) | NA | |
N/Y YD; N Y/F D | 3 (15.0) | 12 (16.9) | 11 (4.3) | 11 (12.8) | NA | 37 (8.5) | 0.0015 | |
Y Y/F D; N/Y FD; N/Y Y/F D; N/Y Y D/Y | 2(10.0) | 5 (7.0) | 8 (3.1) | 4 (4.7) | NA | 19 (4.4) | 0.1928b | |
Sub total | Â | 20 | 71 | 257 | 86 | NA | 434 | Â |