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Table 2 Geographic distribution of pfcrt and pfmdr1 haplotypes in Plasmodium falciparum isolates returned from Africa

From: Molecular surveillance of pfcrt, pfmdr1 and pfk13-propeller mutations in Plasmodium falciparum isolates imported from Africa to China

Gene Haplotypes Number and prevalence of each haplotype in different region of Africa (n/%)  
East Africa West Africa Central Africa South Africa North Africa Total P value
Pfcrt CVMNK (wild type) 43 (75.4) 101 (60.8) 251 (62.4) 53 (58.2) 11 (73.3) 459 (62.8) 0.2216
CVMNT 3 (5.3) 0 1 (0.2) 0 0 4 (0.55) 0.01b
CVIET 7 (12.3) 53 (31.9) 122 (30.3) 29 (31.9) 4 (26.7) 215 (29.4) 0.0598
CVMN K/T 1 (1.8) 0 0 0 0 1 (0.1) 0.0985b
CV M/I N/E K/T 3 (5.3) 12 (7.2) 28(7.0) 9 (9.9) 0 52 (7.1) 0.6406
Sub total   57 166 402 91 15 731  
Pfmdr1 NYD (wild type) 4 (20.0) 23 (32.4) 119 (46.3) 45 (52.3) NA 191 (44.0) 0.0092
YYDa 0 2 (2.8) 16 (6.2) 5 (5.8) NA 23 (5.3) 0.6466b
NYD 6 (30.0) 16 (22.5) 69 (26.8) 16 (18.6) NA 107 (24.7) 0.417
NYY 0 0 0 0 NA 0 NA
YFD 5 (25.0) 12 (16.9) 33 (12.8) 5 (5.8) NA 55 (12.7) 0.0561
YYY 0 1 (1.4) 0 0 NA 1 (0.2) NA
NFY 0 0 1 (0.4) 0 NA 1 (0.2) NA
N/Y YD; N Y/F D 3 (15.0) 12 (16.9) 11 (4.3) 11 (12.8) NA 37 (8.5) 0.0015
Y Y/F D; N/Y FD; N/Y Y/F D; N/Y Y D/Y 2(10.0) 5 (7.0) 8 (3.1) 4 (4.7) NA 19 (4.4) 0.1928b
Sub total   20 71 257 86 NA 434  
  1. aA total of 34 isolates with mixed single mutant haplotypes at 184 Y/F were not included. One isolate with a double mutation at 184 and 1246 was included in NFY and the other with mixed mutations was not included
  2. bFisher's exact test was used to evaluate the difference among the groups if 25% of the cells have expected counts less than 5
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