|
Gene
|
Haplotypes
|
Number and prevalence of each haplotype in different region of Africa (n/%)
| |
|---|
|
East Africa
|
West Africa
|
Central Africa
|
South Africa
|
North Africa
|
Total
|
P value
|
|---|
|
Pfcrt
|
CVMNK (wild type)
|
43 (75.4)
|
101 (60.8)
|
251 (62.4)
|
53 (58.2)
|
11 (73.3)
|
459 (62.8)
|
0.2216
|
|
CVMNT
|
3 (5.3)
|
0
|
1 (0.2)
|
0
|
0
|
4 (0.55)
|
0.01b
|
|
CVIET
|
7 (12.3)
|
53 (31.9)
|
122 (30.3)
|
29 (31.9)
|
4 (26.7)
|
215 (29.4)
|
0.0598
|
|
CVMN K/T
|
1 (1.8)
|
0
|
0
|
0
|
0
|
1 (0.1)
|
0.0985b
|
|
CV M/I N/E K/T
|
3 (5.3)
|
12 (7.2)
|
28(7.0)
|
9 (9.9)
|
0
|
52 (7.1)
|
0.6406
|
|
Sub total
| |
57
|
166
|
402
|
91
|
15
|
731
| |
|
Pfmdr1
|
NYD (wild type)
|
4 (20.0)
|
23 (32.4)
|
119 (46.3)
|
45 (52.3)
|
NA
|
191 (44.0)
|
0.0092
|
|
YYDa
|
0
|
2 (2.8)
|
16 (6.2)
|
5 (5.8)
|
NA
|
23 (5.3)
|
0.6466b
|
|
NYD
|
6 (30.0)
|
16 (22.5)
|
69 (26.8)
|
16 (18.6)
|
NA
|
107 (24.7)
|
0.417
|
|
NYY
|
0
|
0
|
0
|
0
|
NA
|
0
|
NA
|
|
YFD
|
5 (25.0)
|
12 (16.9)
|
33 (12.8)
|
5 (5.8)
|
NA
|
55 (12.7)
|
0.0561
|
|
YYY
|
0
|
1 (1.4)
|
0
|
0
|
NA
|
1 (0.2)
|
NA
|
|
NFY
|
0
|
0
|
1 (0.4)
|
0
|
NA
|
1 (0.2)
|
NA
|
|
N/Y YD; N Y/F D
|
3 (15.0)
|
12 (16.9)
|
11 (4.3)
|
11 (12.8)
|
NA
|
37 (8.5)
|
0.0015
|
|
Y Y/F D; N/Y FD; N/Y Y/F D; N/Y Y D/Y
|
2(10.0)
|
5 (7.0)
|
8 (3.1)
|
4 (4.7)
|
NA
|
19 (4.4)
|
0.1928b
|
|
Sub total
| |
20
|
71
|
257
|
86
|
NA
|
434
| |
- aA total of 34 isolates with mixed single mutant haplotypes at 184 Y/F were not included. One isolate with a double mutation at 184 and 1246 was included in NFY and the other with mixed mutations was not included
- bFisher's exact test was used to evaluate the difference among the groups if 25% of the cells have expected counts less than 5
