Table 3 The distribution of pfk13 mutations in isolates from different countries and geographic regions of Africa

Central Africa

Equatorial Guinea

224

15

C469C(1) R575K(1) A578S(4) C580F(1) D452N(1) M476I(1) V589I(1) P574L(1) A578T(1) M579I(1) C469F(2)

Congo, DRC

32

1

Q613E (1)

Republic of Congo

35

2

I634T (1) A578S (1)

Cameroon

54

1

L457S (1)

Chad

11

0

Central African Republic

3

0

Gabon

14

0

Angola

466

19

P553L(1) A569T(1) A578S(2) Q613E(5) I646K(1) R471R(4) R539T(1) P443R(1) V589I(1) M579I(2)

Sub total

839

38

North Africa

Algeria

1

0

Egypt

1

0

Libya

3

0

Sudan

21

0

Sub total

26

0

East Africa

Ethiopia

8

0

Kenya

6

1

I683R (1)

Tanzania

20

2

Q613E (1) L488V(1)

Uganda

8

1

A578S (1)

Sub total

42

4

West Africa

Mali

5

0

Burkina Faso

2

0

Niger

4

0

Togo

7

0

Ivory Coast

17

0

Benin

9

0

Liberia

25

0

Sierra Leone

29

0

Nigeria

152

3

C469C (1) G496G (1) A627A (1)

Guinea

55

2

M562I (1) A578S (1)

Ghana

65

2

C469C (1) A578S (1)

Sub total

370

7

South Africa

Mozambique

28

0

Zambia

39

0

Malawi

8

0

Madagascar

3

0

Zimbabwe

1

0

South Africa

1

0

Sub total

80

0

Total

1357

49