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Table 3 The distribution of pfk13 mutations in isolates from different countries and geographic regions of Africa

From: Molecular surveillance of pfcrt, pfmdr1 and pfk13-propeller mutations in Plasmodium falciparum isolates imported from Africa to China

Sub-region of Africa Source countries Sample size
(N)
No. of samples with pfk13 mutations Amino acid of pfk13 mutations (n)
Central Africa Equatorial Guinea 224 15 C469C(1) R575K(1) A578S(4) C580F(1) D452N(1) M476I(1) V589I(1) P574L(1) A578T(1) M579I(1) C469F(2)
Congo, DRC 32 1 Q613E (1)
Republic of Congo 35 2 I634T (1) A578S (1)
Cameroon 54 1 L457S (1)
Chad 11 0  
Central African Republic 3 0  
Gabon 14 0  
Angola 466 19 P553L(1) A569T(1) A578S(2) Q613E(5) I646K(1) R471R(4) R539T(1) P443R(1) V589I(1) M579I(2)
Sub total   839 38  
North Africa Algeria 1 0  
Egypt 1 0  
Libya 3 0  
Sudan 21 0  
Sub total   26 0  
East Africa Ethiopia 8 0  
Kenya 6 1 I683R (1)
Tanzania 20 2 Q613E (1) L488V(1)
Uganda 8 1 A578S (1)
Sub total   42 4  
West Africa Mali 5 0  
Burkina Faso 2 0  
Niger 4 0  
Togo 7 0  
Ivory Coast 17 0  
Benin 9 0  
Liberia 25 0  
Sierra Leone 29 0  
Nigeria 152 3 C469C (1) G496G (1) A627A (1)
Guinea 55 2 M562I (1) A578S (1)
Ghana 65 2 C469C (1) A578S (1)
Sub total   370 7  
South Africa Mozambique 28 0  
Zambia 39 0  
Malawi 8 0  
Madagascar 3 0  
Zimbabwe 1 0  
South Africa 1 0  
Sub total   80 0  
Total   1357 49  
  1. Three mutations (M476I, R539T, and P553L) associated with artimisinin resistance confirmed by WHO were shown in bold front