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Table 1 Summary of pKa, LogP, and LogD of SJ733 and SJ311

From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

 

(r)-SJ733

(+)-SJ733

(r)-SJ311

(+)-SJ311

pKa

10.9 ± 0.1; 4.06 ± 0.03a

 

11.1 ± 0.3

 

LogP

2.95 ± 0.03 (logP( +))

 

1.24 ± 0.28 (logP( +))

 

LogD (7.4) Shake flask

 

3.90 ± 0.01a,b

2.34

2.30

  1. aData from Charman et al. [16]
  2. bAveraged from analysis of high and low concentration partition samples, the results of which were highly similar (< 0.01 difference)
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Malaria Journal

ISSN: 1475-2875

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