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Table 1 Summary of pKa, LogP, and LogD of SJ733 and SJ311

From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

  (r)-SJ733 (+)-SJ733 (r)-SJ311 (+)-SJ311
pKa 10.9 ± 0.1; 4.06 ± 0.03a   11.1 ± 0.3  
LogP 2.95 ± 0.03 (logP( +))   1.24 ± 0.28 (logP( +))  
LogD (7.4) Shake flask   3.90 ± 0.01a,b 2.34 2.30
  1. aData from Charman et al. [16]
  2. bAveraged from analysis of high and low concentration partition samples, the results of which were highly similar (< 0.01 difference)
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