Table 4 Summary of microsomal half-life and clearance in vitro of SJ733 and SJ311

Mouse

t_1/2 (h)

0.8 ± 0.1

0.7 ± 0.1

 > 4

 > 4

CLint (µl/min/mg protein)

32.1 ± 2.1

35.4 ± 2.1

 < 7

 < 7

Rat

t_1/2 (h)

 > 4

 > 4

 > 4

 > 4

CLint (µl/min/mg protein)

 < 7

 < 7

 < 7

 < 7

Dog

t_1/2 (h)

2.2 ± 0.4

 > 4

 > 4

 > 4

CLint (µl/min/mg protein)

10.9 ± 1.5

 < 7

 < 7

 < 7

Human

t_1/2 (h)

0.4 ± 0.1

0.5 ± 0.1

 > 4

 > 4

CLint (µl/min/mg protein)

61.7 ± 13.2

45.5 ± 4.0

 < 7

 < 7