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Table 6 Plasma protein binding and whole blood partitioning of (r)-SJ733 and (r)-SJ311

From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

Species (r)-SJ733 (r)-SJ311
% bounda B/P ratio % bounda B/P ratio
Mouse 95.7 ± 0.6   93.7 ± 0.7  
Rat 90.0 ± 1.7   91.0 ± 0.1  
Dog 88.3 ± 3.1   90.0 ± 1.0  
Human 94.3 ± 0.6 0.72 ± 0.02b 95.3 ± 0.6  
  1. aValues of protein binding are average of all high, medium and low concentrations (20, 4, 0.8 µM), all of which were similar. Data are presented as mean ± SD (n = 3)
  2. bValue reported previously [16]
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