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Table 6 Plasma protein binding and whole blood partitioning of (r)-SJ733 and (r)-SJ311

From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

Species

(r)-SJ733

(r)-SJ311

% bounda

B/P ratio

% bounda

B/P ratio

Mouse

95.7 ± 0.6

 

93.7 ± 0.7

 

Rat

90.0 ± 1.7

 

91.0 ± 0.1

 

Dog

88.3 ± 3.1

 

90.0 ± 1.0

 

Human

94.3 ± 0.6

0.72 ± 0.02b

95.3 ± 0.6

 
  1. aValues of protein binding are average of all high, medium and low concentrations (20, 4, 0.8 µM), all of which were similar. Data are presented as mean ± SD (n = 3)
  2. bValue reported previously [16]
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Malaria Journal

ISSN: 1475-2875

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