Table 7 Murine plasma pharmacokinetic parameters of S733 and SJ311 after oral administration
From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones
Dose (mg/kg) | (r)-SJ733 | ( +)-SJ733 | (r)-SJ311 | ||
|---|---|---|---|---|---|
50 | 200 | 10 | 100 | 100 | |
Cmax (µM) | 10.1 ± 4.5 | 12.7 ± 3.2 | 1.38 ± 0.21 | 11.7 ± 1.2 | 10.5 ± 5.3 |
Tmax (h) | 0.5 | 5 | 0.5 | 0.5 | 0.5 |
Half-life (h) | 1.72 | 14.1 | 3.63 | 3.17 | 4.20 |
AUCinf (h µM) | 28 | 155.7 | 4.27 | 53 | 42 |
CL/F (L/h/kg) | 4.02 | 3.25 | 5.00 | 4.02 | 5.34 |
V/F (L/kg) | 18.4 | 3.23 | 26.2 | 18.4 | 32.4 |
F (%) | 70 | 98 | 65 | 80.8 | 23.1 |