Skip to main content

Table 7 Murine plasma pharmacokinetic parameters of S733 and SJ311 after oral administration

From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

Dose (mg/kg) (r)-SJ733 ( +)-SJ733 (r)-SJ311
  50 200 10 100 100
Cmax (µM) 10.1 ± 4.5 12.7 ± 3.2 1.38 ± 0.21 11.7 ± 1.2 10.5 ± 5.3
Tmax (h) 0.5 5 0.5 0.5 0.5
Half-life (h) 1.72 14.1 3.63 3.17 4.20
AUCinf (h µM) 28 155.7 4.27 53 42
CL/F (L/h/kg) 4.02 3.25 5.00 4.02 5.34
V/F (L/kg) 18.4 3.23 26.2 18.4 32.4
F (%) 70 98 65 80.8 23.1
  1. % F was calculated using the equation: (AUCinf PO / mean AUCinf IV) • (Dose IV / Dose PO). Cmax values are mean ± SD, n = 3 or 4. AUCinf, CL and V were estimated from mean plasma concentration values from different animals in a single study; error or SDs for the parameters were not estimated
\