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Table 9 Dog pharmacokinetic parameters of S733 and SJ311 after oral administration

From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

Dose (mg/kg) (+)-SJ733 (+)-SJ311
3 30 3 30
Cmax (µM) 3.0 ± 0.7 25.6 ± 2.1 4.0 ± 0.8 35.0 ± 5.1
Tmax (h) 0.83 1.67 3.3 ± 1.2 3.0 ± 1.7
Half life (h) 11.4 ± 5.0 5.3 ± 0.7 6.1 ± 0.6 6.7 ± 1.4
AUCinf (h.µM) 40.6 ± 12.9 243 ± 52.9 56.2 ± 12.1 601 ± 137
CL (L/h/kg) 0.169 ± 0.055 0.274 ± 0.067 0.121 ± 0.030 0.113 ± 0.025
V (L/kg) 2.6 ± 0.8 2.1 ± 0.8 1.1 ± 0.4 1.1 ± 0.4
F% 115 ± 29 73.7 ± 16.1 73.0 ± 15.8 77.9 ± 17.7
Dose in urine (%) 2.8 ± 0.2 3.1 ± 1.9 34.7 ± 15.9 33.4
  1. Data are presented as mean ± SD (n = 3)
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