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Table 1 Summary of parasite growth and clearance characteristics

From: Development and evaluation of a new Plasmodium falciparum 3D7 blood stage malaria cell bank for use in malaria volunteer infection studies

Parameter 3D7-V1 (n = 2) Estimate (95% CI) 3D7-MBE-008 (n = 2) Estimate (95% CI) 3D7-V1 1995 (n = 1) Estimate (95% CI) 3D7-V2 (n = 177) Estimate (95% CI) [25]
PMR48 11.5 (8.5–15.6) 34.6 (18.5–64.6) 6.4 (4.6–8.8) 31.9 (28.7–35.4)
Lifecycle (hours) 36.5 (35.0–38.0) 38.8 (36.7–40.8) 42.5 (39.2–45.8) 38.8 (38.3–39.2)
Growth rate (log10 parasites/day) 0.52 (0.30–0.74) 0.80 (0.54 –1.10) 0.35 (0.13–0.58) 0.63 (0.59–0.66)
PRR48 2254 (1705–2979) 3806 (1446–10018) _ _
log10 PRR48 3.35 (3.23–3.47) 3.58 (3.16–4.00) _ _
Parasite clearance half life 4.31 (4.16–4.47) 4.04 (3.61–4.57) _ _
  1. n, number of participants; CI, 95% confidence intervals; PMR, parasite multiplication rate; PRR, parasite reduction ratio. Growth parameter estimates are calculated from a non-linear mixed effects model. Clearance parameter estimates (PRR48, log10 PRR48 and parasite clearance half-life) are calculated from a weighted mean of individual clearance parameters estimates
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