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Table 3 SNPs included in the analysis and association with malaria infection

From: Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso

Gene SNPs Alleles or genotypes Model Univariate analysis Multivariate analysisa
OR (95%CI) P AOR (95%CI) P
Allele-based analysis
 TLR1 rs4833095 T vs C 0.80 (0.51–1.24) 0.318 0.89 (0.54–1.47) 0.660
 TLR4 rs4986790 G vs A 1.15 (0.70–1.88) 0.581 1.44 (0.82–2.53) 0.204
 TLR9 rs5743836 G vs A 1.01 (0.76–1.32) 0.972 0.98 (0.72–1.33) 0.760
 TLR9 rs352139 T vs C 1.13 (0.85–1.49) 0.384 1.22 (0.89–1.66) 0.219
 IL-4 rs2243250 C vs T 0.91 (0.66–1.27) 0.606 0.89 (0.63–1.27) 0.534
 IL-10 rs1800896 C vs T 1.07 (0.78–1.46) 0.664 1.07 (0.76–1.53) 0.685
 IL-10 rs1800890 T vs A 1.04 (0.73–1.46) 0.835 1.10 (0.75–1.61) 0.614
 IL-17F rs4715291 T vs C 1.23 (0.83–1.82) 0.305 1.11 (0.72–1.71) 0.629
 IL-1β rs1143634 A vs G 0.58 (0.400.86) 0.006 0.52 (0.340.80) 0.003
 TNF-α rs1800629 A vs G 0.86 (0.59–1.26) 0.444 0.91 (0.60–1.38) 0.669
 TNF-α rs3093664 G vs A 0.88 (0.50–1.56) 0.663 0.93 (0.48–1.78) 0.826
 IFNR1 rs10213701 A vs T 1.02 (0.77–1.35) 0.891 0.97 (0.71–1.34) 0.888
 IFNR1 rs10065633 C vs T 1.12 (0.84–1.47) 0.407 1.20 (0.88–1.63) 0.238
 NOS2A rs2297518 A vs G 1.32 (0.77–2.26) 0.306 1.28 (0.71–2.33) 0.408
 FcγRIIA/CD32 rs1801274 A vs G 0.62 (0.470.82) < 0.001 0.51 (0.370.70) < 0.001
Genotype-based analysisb
 TLR1 rs4833095 TT vs TC/CC Recessive 0.60 (0.11–3.14) 0.423 0.57 (0.10–3.18) 0.521
 TLR4 rs4986790 GA/GG vs AA Dominant 1.11 (0.66–1.86) 0.828 1.43 (0.79–2.58) 0.237
 TLR9 rs5743836 GG vs GA/AA Recessive 0.87 (0.54–1.40) 0.565 0.95 (0.56–1.62) 0.861
 TLR9 rs352139 TT vs TC/CC Recessive 1.30 (0.79–2.14) 0.291 1.57 (0.89–2.77) 0.117
 IL-4 rs2243250 TC vs TT/CC Over-dominant 0.93 (0.62–1.40) 0.730 0.91 (0.58–1.43) 0.695
 IL-10 rs1800896 CT vs TT/CC Over-dominant 1.32 (0.86–2.02) 0.201 1.60 (0.99–2.61) 0.057
 IL-10 rs1800890 TA vs TT/AA Over-dominant 1.33 (0.86–2.07) 0.203 1.52 (0.93–2.48) 0.098
 IL-17F rs4715291 TT vs TC/CC Recessive 1.15 (0.73–1.83) 0.537 1.28 (0.35–4.61) 0.710
 IL-1β rs1143634 AG/AA vs GG Dominant 0.58 (0.370.89) 0.013 0.52 (0.320.84) 0.007
 TNF-α rs1800629 AA vs GA/GG Recessive 1.34 (0.29–6.13) 0.704 1.41 (0.28–7.10) 0.677
 TNF-α rs3093664 GA vs GG/AA Over-dominant 0.74 (0.41–1.35) 0.325 0.77 (0.39–1.52) 0.454
 IFNR1 rs10065633 TC vs CC/TT Over-dominant 0.89 (0.61–1.32) 0.574 0.90 (0.58–1.37) 0.619
 IFNR1 rs10213701 TA vs AA/TT Over-dominant 0.85 (0.58–1.25) 0.415 0.86 (0.56–1.32) 0.492
 NOS2A rs2297518 GA/AA vs GG Over-dominant 1.32 (0.74–2.34) 0.342 1.30 (0.69–2.46) 0.421
FcγRIIA/CD32 rs1801274 GA/AA vs GG Dominant 0.52 (0.340.78) 0.001 0.45 (0.280.70) < 0.001
  1. Significant P values < 0.05 are indicated in italics
  2. aAdjusted by mother’s age, gravidity, Birth season, baby’s sex, LBW, Prenatal malaria exposure, ethnicity, Haemoglobin variants
  3. bGenotype-based analysis for dominant, over-dominant and recessive models. Models that showed lowest P values are shown