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Table 4 SNPs included in the analysis and association with clinical malaria

From: Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso

Gene SNPs Alleles/genotypes Model Univariate analysis Multivariate analysisa
OR (95%CI) P OR (95%CI) P
Allele-based analysis
 TLR1 rs4833095 T vs C 0.90 (0.62–1.33) 0.608 0.96 (0.63–1.46) 0.844
 TLR4 rs4986790 G vs A 1.04 (0.70–1.54) 0.838 1.19 (0.76–1.87) 0.442
 TLR9 rs5743836 G vs A 0.89 (0.71–1.12) 0.324 0.82 (0.64–1.06) 0.137
 TLR9 rs352139 T vs C 1.13 (0.90–1.42) 0.296 1.09 (0.84–1.40) 0.524
 IL-4 rs2243250 C vs T 1.04 (0.79–1.36) 0.772 0.97 (0.72–1.31) 0.857
 IL-10 rs1800896 C vs T 1.05 (0.82–1.35) 0.676 1.00 (0.76–1.33) 0.982
 IL-10 rs1800890 T vs A 1.17 (0.88–1.56) 0.268 1.14 (0.83–1.56) 0.423
 IL-17F rs4715291 T vs C 1.12 (0.82–1.53) 0.462 0.98 (0.70–9.07) 0.918
 IL-1β rs1143634 A vs G 0.68 (0.480.95) 0.025 0.66 (0.460.97) 0.032
 TNF-α rs1800629 A vs G 0.97 (0.70–1.33) 0.843 1.08 (0.76–1.53) 0.682
 TNF-α rs3093664 G vs A 0.82 (0.51–1.32) 0.406 0.73 (0.43–1.25) 0.259
 IFNR1 rs10213701 A vs T 1.11 (0.88–1.41) 0.361 1.15 (0.89–1.50) 0.283
 IFNR1 rs10065633 C vs T 1.02 (0.82–0.82) 0.843 1.06 (0.82–1.36) 0.644
 NOS2A rs2297518 A vs G 1.09 (0.72–1.65) 0.682 1.32 (0.83–2.10) 0.239
 FcγRIIA/CD32 rs1801274 A vs G 0.71 (0.560.90) 0.005 0.68 (0.520.89) 0.005
Genotype-based analysisb
 TLR1 rs4833095 TT vs TC/CC Recessive 0.44 (0.10–1.99) 0.286 0.50 (0.11–2.36) 0.388
 TLR4 rs4986790 GA/GG vs AA Dominant 1.02 (0.67–1.56) 0.910 1.28 (0.79–2.06) 0.313
 TLR9 rs5743836 GG vs GA/AA Recessive 0.81 (0.54–1.20) 0.295 0.77 (0.50–1.20) 0.250
 TLR9 rs352139 TT vs TC/CC Recessive 1.33 (0.90–1.98) 0.155 1.33 (0.86–2.06) 0.197
 IL-4 rs2243250 TC vs TT/CC Over-dominant 0.96 (0.68–1.35) 0.818 0.83 (0.57–1.20) 0.326
 IL-10 rs1800896 CT vs TT/CC Over-dominant 1.07 (0.76–1.50) 0.690 1.29 (0.88–1.88) 0.185
 IL-10 rs1800890 TA vs TT/AA Over-dominant 1.41 (0.99–2.01) 0.059 1.48 (0.99–2.19) 0.052
 IL-17F rs4715291 TT vs TC/CC Recessive 1.29 (0.52–3.02) 0.583 0.92 (0.35–2.46) 0.882
 IL-1β rs1143634 AA vs AG/GG Recessive 0.29 (0.071.18) 0.086 0.14 (0.030.78) 0.024
 TNF-α rs1800629 AA vs GA/GG Recessive 1.34 (0.41–4.41) 0.626 2.15 (0.54–8.59) 0.279
 TNF-α rs3093664 GA vs GG/AA Over-dominant 0.85 (0.50–1.42) 0.529 0.70 (0.40–1.25) 0.230
 IFNR1 rs10065633 TC vs CC/TT Over-dominant 1.03 (0.75–1.41) 0.869 1.14 (0.80–1.61) 0.476
 IFNR1 rs10213701 TA/AA vs TT Dominant 1.13 (0.82–1.55) 0.468 1.20 (0.84–1.70) 0.331
 NOS2A rs2297518 GA/AA vs GG Dominant 1.11 (0.71–1.73) 0.656 1.30 (0.79–2.14) 0.307
 FcγRIIA/CD32 rs1801274 GA/AA vs GG Dominant 0.65 (0.470.89) 0.008 0.58 (0.410.84) 0.003
  1. Significant P values < 0.05 are indicated in italics
  2. aAdjusted by mother’s age, gravidity, birth season, baby’s gender, low birth weight, Prenatal malaria exposure, ethnicity, Haemoglobin variant
  3. bGenotype-based analysis for dominant, over-dominant and recessive models. Models that showed lowest P values (P) are shown
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