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Table 4 SNPs included in the analysis and association with clinical malaria

From: Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso

Gene

SNPs

Alleles/genotypes

Model

Univariate analysis

Multivariate analysisa

OR (95%CI)

P

OR (95%CI)

P

Allele-based analysis

 TLR1

rs4833095

T vs C

0.90 (0.62–1.33)

0.608

0.96 (0.63–1.46)

0.844

 TLR4

rs4986790

G vs A

1.04 (0.70–1.54)

0.838

1.19 (0.76–1.87)

0.442

 TLR9

rs5743836

G vs A

0.89 (0.71–1.12)

0.324

0.82 (0.64–1.06)

0.137

 TLR9

rs352139

T vs C

1.13 (0.90–1.42)

0.296

1.09 (0.84–1.40)

0.524

 IL-4

rs2243250

C vs T

1.04 (0.79–1.36)

0.772

0.97 (0.72–1.31)

0.857

 IL-10

rs1800896

C vs T

1.05 (0.82–1.35)

0.676

1.00 (0.76–1.33)

0.982

 IL-10

rs1800890

T vs A

1.17 (0.88–1.56)

0.268

1.14 (0.83–1.56)

0.423

 IL-17F

rs4715291

T vs C

1.12 (0.82–1.53)

0.462

0.98 (0.70–9.07)

0.918

 IL-1β

rs1143634

A vs G

0.68 (0.480.95)

0.025

0.66 (0.460.97)

0.032

 TNF-α

rs1800629

A vs G

0.97 (0.70–1.33)

0.843

1.08 (0.76–1.53)

0.682

 TNF-α

rs3093664

G vs A

0.82 (0.51–1.32)

0.406

0.73 (0.43–1.25)

0.259

 IFNR1

rs10213701

A vs T

1.11 (0.88–1.41)

0.361

1.15 (0.89–1.50)

0.283

 IFNR1

rs10065633

C vs T

1.02 (0.82–0.82)

0.843

1.06 (0.82–1.36)

0.644

 NOS2A

rs2297518

A vs G

1.09 (0.72–1.65)

0.682

1.32 (0.83–2.10)

0.239

 FcγRIIA/CD32

rs1801274

A vs G

0.71 (0.560.90)

0.005

0.68 (0.520.89)

0.005

Genotype-based analysisb

 TLR1

rs4833095

TT vs TC/CC

Recessive

0.44 (0.10–1.99)

0.286

0.50 (0.11–2.36)

0.388

 TLR4

rs4986790

GA/GG vs AA

Dominant

1.02 (0.67–1.56)

0.910

1.28 (0.79–2.06)

0.313

 TLR9

rs5743836

GG vs GA/AA

Recessive

0.81 (0.54–1.20)

0.295

0.77 (0.50–1.20)

0.250

 TLR9

rs352139

TT vs TC/CC

Recessive

1.33 (0.90–1.98)

0.155

1.33 (0.86–2.06)

0.197

 IL-4

rs2243250

TC vs TT/CC

Over-dominant

0.96 (0.68–1.35)

0.818

0.83 (0.57–1.20)

0.326

 IL-10

rs1800896

CT vs TT/CC

Over-dominant

1.07 (0.76–1.50)

0.690

1.29 (0.88–1.88)

0.185

 IL-10

rs1800890

TA vs TT/AA

Over-dominant

1.41 (0.99–2.01)

0.059

1.48 (0.99–2.19)

0.052

 IL-17F

rs4715291

TT vs TC/CC

Recessive

1.29 (0.52–3.02)

0.583

0.92 (0.35–2.46)

0.882

 IL-1β

rs1143634

AA vs AG/GG

Recessive

0.29 (0.071.18)

0.086

0.14 (0.030.78)

0.024

 TNF-α

rs1800629

AA vs GA/GG

Recessive

1.34 (0.41–4.41)

0.626

2.15 (0.54–8.59)

0.279

 TNF-α

rs3093664

GA vs GG/AA

Over-dominant

0.85 (0.50–1.42)

0.529

0.70 (0.40–1.25)

0.230

 IFNR1

rs10065633

TC vs CC/TT

Over-dominant

1.03 (0.75–1.41)

0.869

1.14 (0.80–1.61)

0.476

 IFNR1

rs10213701

TA/AA vs TT

Dominant

1.13 (0.82–1.55)

0.468

1.20 (0.84–1.70)

0.331

 NOS2A

rs2297518

GA/AA vs GG

Dominant

1.11 (0.71–1.73)

0.656

1.30 (0.79–2.14)

0.307

 FcγRIIA/CD32

rs1801274

GA/AA vs GG

Dominant

0.65 (0.470.89)

0.008

0.58 (0.410.84)

0.003

  1. Significant P values < 0.05 are indicated in italics
  2. aAdjusted by mother’s age, gravidity, birth season, baby’s gender, low birth weight, Prenatal malaria exposure, ethnicity, Haemoglobin variant
  3. bGenotype-based analysis for dominant, over-dominant and recessive models. Models that showed lowest P values (P) are shown