Fig. 1

CD141⁺ DCs decline in malaria-naive volunteers experimentally infected with P. falciparum. a CD141⁺ DC gating. CD141⁺ DCs were identified as negative for lineage markers, HLA-DR⁺, CD11c⁺ and CD141⁺. b The absolute number of circulating CD141⁺ DCs in malaria naive volunteers experimentally infected with P. falciparum (d0; n = 33, − 24 h to peak; n = 26, peak; n = 33, + 24 h to peak n = 26). c Plasma Flt3L levels in malaria-naive volunteers experimentally infected with P. falciparum before infection (day 0) and at day predefined threshold for treatment reached (peak), n = 7. d Correlation of CD141⁺ DC number and Flt3L concentration on day 0 (left plot), correlation of CD141⁺ DC number and Flt3L concentration at peak infection (middle plot) and correlation of CD141⁺ DC number at peak infection and Flt3L concentration at day 0 (right plot) in volunteer infection studies. Box plots show the 10–90th percentile, median and interquartile range for data from all participants. The Wilcoxon matched-paired sign rank test was used to compare matched data. Spearman correlation was used for linear regression tests. Tests were two-tailed and considered significant if p-values < 0.05