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Fig. 2 | Malaria Journal

Fig. 2

From: Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels

Fig. 2

DC subsets decline in adults with acute clinical malaria. a DC subsets were identified as negative for lineage markers and HLA-DR+. Specifically, pDC were identified by CD303+ expression; CD1c+ DC were identified by CD1c+ (BDCA1) expression and CD141+ by CD141+ (BDCA3) expression. The absolute number of circulating b pDC (red), c CD1c+ DC (green) and d CD141+ DC (blue) in clinical malaria patients with P. falciparum (acute n = 7, conval = 6, circles) or P. knowlesi (acute n = 12, conval = 8, triangles) compared to local healthy controls (n = 5, healthy, squares). Box plots show the 10–90th percentile, median and interquartile range for data from all participants. The Mann–Whitney T-test was used to compare unpaired data (healthy vs acute and healthy vs conval). Tests were two-tailed and considered significant if p-values < 0.05

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