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Fig. 4 | Malaria Journal

Fig. 4

From: Ecology of asynchronous asexual replication: the intraerythrocytic development cycle of Plasmodium berghei is resistant to host rhythms

Fig. 4

IDC rhythms and cumulative parasite densities in hosts with (TRF) and without (all-day fed) feeding and food-associated rhythms. All hosts were arrhythmic Per1/2-null mice (n = 4), either given access to food continuously (all-day fed; solid line) or during an 8 h window each day (time restricted feeding (TRF); dashed line). Shown are (a) the mean ring stage proportion ± SEM in shading and (b) mean cumulative parasite density ± SEM in shading (0-28 h sampling period; days 5-6PI). Green boxes in a represent period when food is available to TRF mice. All mice were housed in continuous darkness so black and grey bars represent day and night UTC

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