Table 3 Distribution of KIR and HLA-C genetic variants at the 3 sites in Uganda
Genetic variants | Study sites | ||
|---|---|---|---|
Tororo, N = 438 n (%) | Jinja, N = 414 n (%) | Kanungu, N = 446 n (%) | |
KIR genes | |||
 2DS2 | 224 (51.1) | 218 (52.7) | 228 (51.1) |
 2DL2 | 254 (58.0) | 240 (58.0) | 254 (57.0) |
 2DL3 | 366 (83.6) | 352 (85.0) | 380 (85.2) |
 2DP1 | 432 (98.6) | 409 (98.8) | 442 (99.1) |
 2DL1 | 432 (98.6) | 409 (98.8) | 441 (98.9) |
 3DL1 | 421 (96.1) | 394 (95.2) | 439 (98.4) |
 3DS1 | 58 (13.2) | 75 (18.1) | 34 (7.6) |
 2DL5 | 291 (66.4) | 264 (63.8) | 255 (57.2) |
 2DS5 | 204 (46.6) | 180 (43.5) | 148 (33.2) |
 2DS3 | 92 (21.0) | 84 (20.3) | 111 (24.9) |
 2DS1 | 117 (26.7) | 126 (30.4) | 88 (19.7) |
 2DS4 | 424 (96.8) | 392 (94.7) | 438 (98.2) |
|  | Tororo, N = 385 n (%) | Jinja, N = 392 n (%) | Kanungu, N = 433 n (%) |
|---|---|---|---|
KIR genotypes | |||
 AA | 150 (39.0) | 133 (33.9) | 171 (39.5) |
 BX | 235 (61.0) | 259 (66.1) | 262 (60.5) |
|  | Tororo, N = 356 n (%) | Jinja, N = 168 n (%) | Kanungu, N = 405 n (%) |
|---|---|---|---|
HLA-C allotypes | |||
 C1C1 | 66 (18.5) | 39 (23.2) | 75 (18.5) |
 C1C2 | 195 (54.8) | 93 (55.4) | 202 (49.9) |
 C2C2 | 95 (26.7) | 36 (21.4) | 128 (31.6) |
|  | Tororo, N = 438 n (%) | Jinja, N = 414 n (%) | Kanungu, N = 446 n (%) |
|---|---|---|---|
Centromeric KIR region | |||
 CenAA | 191 (43.6) | 171 (41.3) | 190 (42.6) |
 CenAB | 175 (40.0) | 182 (44.0) | 192 (43.1) |
 CenBB | 72 (16.4) | 61 (14.7) | 64 (14.3) |
|  | Tororo, N = 438 n (%) | Jinja, N = 413 n (%) | Kanungu, N = 446 n (%) |
|---|---|---|---|
Telomeric KIR region | |||
 TelAA | 314 (71.7) | 283 (68.5) | 356 (79.8) |
 TelAB | 115 (26.3) | 112 (27.1) | 83 (18.6) |
 TelBB | 9 (2.0) | 18 (4.4) | 7 (1.6) |
|  | Tororo, N = 313 n (%) | Jinja, N = 152 n (%) | Kanungu, N = 393 n (%) |
|---|---|---|---|
Combinations of KIR haplotypes/HLA-C | |||
 AA/C1C1 | 21 (6.7) | 11 (7.3) | 22 (5.6) |
 AA/C1C2 | 62 (19.8) | 37 (24.3) | 93 (23.7) |
 AA/C2C2 | 37 (11.8) | 11 (7.2) | 46 (11.7) |
 BX/C1C1 | 36 (11.5) | 23 (15.1) | 50 (12.7) |
 BX/C1C2 | 109 (34.8) | 46 (30.3) | 105 (26.7) |
 BX/C2C2 | 48 (15.4) | 24 (15.8) | 77 (19.6) |