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Table 5 Drug resistance-conferring allele’s frequency across the 5 P. falciparum populations

From: Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia

Genes

Chromosome

Position

Mutation site

Ethiopia

Cambodia

DR Congo

Malawi

Thailand

DHFR

4

748,577

I164L

0

0.5

0

0

0.84

DHFR

4

748,410

S108N

0

1

1

1

1

DHFR

4

748,262

C59R

0.86

1

0.86

0.99

1

DHFR

4

748,239

N51I

1

0.95

1

1

0.95

MDR1

5

961,625

D1246Y

0

0

0.17

0

0

MDR1

5

958,145

N86Y

0.14

0

0.48

0.03

0

MDR1

5

961,566

F1226Y

0

0.04

0

0

0.59

MDR1

5

958,440

Y184F

1

0.58

0.32

0.35

0.06

CRT

7

405,600

I356T

0

0.52

0.27

0

1

CRT

7

405,362

N326S

0.98

0.51

0

0

1

CRT

7

405,838

R371I

0

0.8

0.71

0

1

CRT

7

404,407

A220S

1

1

0.663

0

1

CRT

7

403,625

K76T

1

1

0.66

0

1

CRT

7

404,836

Q271E

1

1

0.7143

0

1

DHPS

8

549,685

G437A

0.08

0.13

0.08

0.01

0

DHPS

8

549,995

K540N

0

0.4

0

0

0.03

DHPS

8

549,681

S436A

0

0.2

0.11

0.02

0.17

DHPS

8

550,117

A581G

0.02

0.4

0.03

0.02

0.82

K13

13

1,726,432

K189T

0.2

0

0.17

0.13

0

K13

13

1,725,259

C580Y

0

0.36

0

0

0.26