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Table 5 Drug resistance-conferring allele’s frequency across the 5 P. falciparum populations

From: Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia

Genes Chromosome Position Mutation site Ethiopia Cambodia DR Congo Malawi Thailand
DHFR 4 748,577 I164L 0 0.5 0 0 0.84
DHFR 4 748,410 S108N 0 1 1 1 1
DHFR 4 748,262 C59R 0.86 1 0.86 0.99 1
DHFR 4 748,239 N51I 1 0.95 1 1 0.95
MDR1 5 961,625 D1246Y 0 0 0.17 0 0
MDR1 5 958,145 N86Y 0.14 0 0.48 0.03 0
MDR1 5 961,566 F1226Y 0 0.04 0 0 0.59
MDR1 5 958,440 Y184F 1 0.58 0.32 0.35 0.06
CRT 7 405,600 I356T 0 0.52 0.27 0 1
CRT 7 405,362 N326S 0.98 0.51 0 0 1
CRT 7 405,838 R371I 0 0.8 0.71 0 1
CRT 7 404,407 A220S 1 1 0.663 0 1
CRT 7 403,625 K76T 1 1 0.66 0 1
CRT 7 404,836 Q271E 1 1 0.7143 0 1
DHPS 8 549,685 G437A 0.08 0.13 0.08 0.01 0
DHPS 8 549,995 K540N 0 0.4 0 0 0.03
DHPS 8 549,681 S436A 0 0.2 0.11 0.02 0.17
DHPS 8 550,117 A581G 0.02 0.4 0.03 0.02 0.82
K13 13 1,726,432 K189T 0.2 0 0.17 0.13 0
K13 13 1,725,259 C580Y 0 0.36 0 0 0.26