Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis

Table 2 Result of genetic diversity, natural selection and recombination among global PfTRAP sequences

Countries	n	S	H	Hd	π	Tajima’s D	dN-dS	Rm	Rb
Africa
Bioko	119	100	87	0.99	0.01046	− 0.41438	6.2231*	22	119
Congo	54	76	51	0.997	0.01029	− 0.08216	6.3986*	19	298
Gambia	34	65	28	0.985	0.01025	0.04683	6.9506*	16	372
Ghana	228	87	193	0.9968	0.01075	0.47289	7.0314*	27	287
Guinea	49	73	43	0.993	0.009778	− 0.19876	6.6430*	21	162
Malawi	106	75	84	0.993	0.01066	0.61245	6.0216*	26	124
Mali	39	67	39	0.999	0.01043	0.12807	7.4272*	16	339
Senegal	110	76	64	0.977	0.01006	0.32976	7.2140*	19	142
Asia
Thailand	104	40	29	0.947	0.00546	0.61617	4.6708*	14	62.4
Vietnam	60	40	26	0.957	0.00567	0.37851	5.0222*	12	45.2
Myanmar	45	40	22	0.954	0.00507	− 0.22333	4.8873*	10	40.4
Bangladesh	23	53	23	1	0.00769	− 0.34671	5.8936*	14	53.7
Cambodia	393	47	71	0.924	0.00517	0.52199	4.8661*	18	35
Laos	42	41	25	0.961	0.00614	0.21991	5.2813*	11	52

n for number of sequences; S for segregating sites; H number of haplotypes; Hd for haplotype diversity; π for nucleotide diversity; dN for number of non-synonymous substitutions per non-synonymous site; dS for number of synonymous substitutions per synonymous site; Rm for minimum number of recombination event; Rb for the probability of recombination between adjacent sites; * for p < 0.05

ISSN: 1475-2875