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Table 1 Summary of studies reporting the yield of malaria reactive case detection

From: What is the yield of malaria reactive case detection in the Greater Mekong Sub-region? A review of published data and meta-analysis

Reference Location Study period Index case(s) Contacts screened Yield by
Microscopy RDT PCR
Rogawski et al. [6] Bo Rai district, Trat province, Thailand 2011 1 index case, hospitalised with mixed P. falciparum–P. vivax infection, identified through passive case detection 126 neighbours within 1 km of the index case were screened
61 soldiers and neighbouring villages with a high proportion of migrants were screened
Microscopist at local malaria clinic—0 detected
Expert microscopist—1 in 187 (0.53%): P. falciparum
Not done or not reported 4 in 187 (2.14%), including the P. falciparum case detected by microscopy and 3 P. vivax cases, which were subsequently confirmed by microscopic examination of more fields
Xiao et al. [7] Yingjiang County, Yunnan Province (China-Myanmar border), China 2014 Persons living around index cases within a radius of 100 m, 300 m, 500 m, and 1 km were screened 278 persons screened 3 in 278 (1.08%) malaria positive Not done or not reported 6 in 278 (2.16%) malaria positive, all within 300 m radius around the index case
Hustedt J, et al. [8] Pailin, Cambodia 2013–2014 270 index cases (91% P. vivax) identified through passive case detection and followed-up at home within 3 days Household members of index cases were screened. For every 15th index case identified, the five nearest households to the index case’s household were invited to participate
For every 30th index case, the ten nearest households were invited to participate
Not done or not reported 9 in 1898 (0.47%) members of index and neighbour households: 7 P. vivax and 2 P. falciparum 17 in 1596 (1.07%) members of index and neighbour households: 15 P. vivax and 2 P. falciparum/P. vivax-mixed
Wang et al. [9] Four counties in Yunnan Province, (China-Myanmar border), China 2012 to 2014 260 index cases reported and investigated, of which 182/260 (70.0%) had contacts screened 3,662 persons screened 10/3,662 (0.27%) malaria positive Not done or not reported
Feng et al. [10] China 2013 to 2014 101 cases reported and were categorized as residual non-active foci 2,985 members of index case’s household and neighbouring households within a 300-m radius were screened Not done or not reported 4/2,985 (0.13%) malaria positive RDT results verified by PCR at the Chinese Center for Disease Control and Prevention
2015 28 indigenous cases were reported, and active foci response was carried out for all of them 1,447 members of index case’s household and neighbouring households within a 300-m radius were screened Not done or not reported 2/1,447 (0.14%) malaria positive
Rossi et al. [11] Chey Saen district, Preah Vihear province, Cambodia 2015 to 2017 194 index cases of P. falciparum malaria infection were identified 785 contacts screened:
623 household members of each index case were screened
162 “Co-exposed” individuals, mainly coworkers in settings with a high malaria infection risk, such as forests or plantations, were screened
Not done or not reported 7/785 (0.89%)
1/623 (0.2%) household members positive
6/162 (3.7%) co-workers positive
31/785 (3.95%)
20/623 (3.2%) household members positive
11/162 (6.8%) co-workers positive
Kheang et al. [12] Sampov Loun, Cambodia 2015 to 2017 408 index cases identified 1,377 contacts screened, including members of index’s and surrounding household and co-travellers (persons who have been working, traveling, or staying outside of the home village with an index case in the past 3–4 weeks) 14/1,377 (1.02%) positive cases (nine P. falciparum and five P. vivax). All positive cases were identified among index case co-travellers; there were no cases identified among index household members or surrounding household members Not done or not reported
Lek et al. [13] Pailin 2013 270 index cases 1898 screened Not done or not reported 9 (0.47%) positive 17 (0.90%) positive
Sampov Loun 2015–2018 639 index cases 1946 screened Not done or not reported 15 (0.77%) positive Not done
Preah Vihear 2016–2018 60 index cases 226 screened Not done or not reported 2 (0.88%) positive 8 (3.54%) positive
Oddar Meanchey 2017–2018 192 index cases 1574 screened Not done or not reported 26 (1.65%) positive 66 (4.19%) positive
  1. Number of malaria positive in contacts screened (%) by diagnostic test used is indicated in bold