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Table 4 Incidence rate per 100,000 person-years of meningitis cases

From: Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS,S/AS01E malaria vaccine

  Incidence rate per 100,000 person-years
n Person-years Value (95% CI)
Kombewa, Kenya (N = 2111)
 Aetiology-confirmed meningitis 1 1249 80 (2, 446)
 Probable meningitis 0 1249 0 (0, 295)
 Clinically suspected meningitis 2 1249 160 (19, 579)
 Aetiology-confirmed, probable, and/or clinically suspected meningitis 3 1248 240 (50, 703)
 Suspected meningitis ruled out afterward 1 1249 80 (2, 446)
Kintampo, Ghana (N = 3603)
 Aetiology-confirmed meningitisa 1 2330 43 (1, 239)
 Probable meningitis 0 2330 0 (0, 158)
 Clinically suspected meningitis 0 2330 0 (0, 158)
 Aetiology-confirmed, probable, and/or clinically suspected meningitis 1 2330 43 (1, 239)
 Suspected meningitis ruled out afterward 0 2330 0 (0, 158)
Navrongo, Ghana (N = 1183)
 Aetiology-confirmed meningitis 0 754 0 (0, 490)
 Probable meningitis 0 754 0 (0, 490)
 Clinically suspected meningitis 0 754 0 (0, 490)
 Aetiology-confirmed, probable, and/or clinically suspected meningitis 0 754 0 (0, 490)
 Suspected meningitis ruled out afterward 0 754 0 (0, 490)
Overall (N = 6897)
 Aetiology-confirmed meningitisa 2 4332 46 (6, 167)
 Probable meningitis 0 4332 0 (0, 85)
 Clinically suspected meningitis 2 4332 46 (6, 167)
 Aetiology-confirmed, probable, and/or clinically suspected meningitis 4 4331 92 (25, 236)
 Suspected meningitis ruled out afterward 1 4332 23 (1, 129)
  1. According-to-protocol cohort, 5 to 17 months age-group
  2. N, number of study participants at risk during a follow-up period of approximately 6 months after each dose of the virtual primary vaccination schedule censored at the next dose; n, number of cases reported during that follow-up period; CI: confidence interval; M: Months
  3. aOne case of aetiology-confirmed meningitis has been downgraded to probable meningitis after the interim analysis (see text for details)