Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS,S/AS01E malaria vaccine

Table 4 Incidence rate per 100,000 person-years of meningitis cases

	Incidence rate per 100,000 person-years
	n	Person-years	Value (95% CI)
Kombewa, Kenya (N = 2111)
Aetiology-confirmed meningitis	1	1249	80 (2, 446)
Probable meningitis	0	1249	0 (0, 295)
Clinically suspected meningitis	2	1249	160 (19, 579)
Aetiology-confirmed, probable, and/or clinically suspected meningitis	3	1248	240 (50, 703)
Suspected meningitis ruled out afterward	1	1249	80 (2, 446)
Kintampo, Ghana (N = 3603)
Aetiology-confirmed meningitis^a	1	2330	43 (1, 239)
Probable meningitis	0	2330	0 (0, 158)
Clinically suspected meningitis	0	2330	0 (0, 158)
Aetiology-confirmed, probable, and/or clinically suspected meningitis	1	2330	43 (1, 239)
Suspected meningitis ruled out afterward	0	2330	0 (0, 158)
Navrongo, Ghana (N = 1183)
Aetiology-confirmed meningitis	0	754	0 (0, 490)
Probable meningitis	0	754	0 (0, 490)
Clinically suspected meningitis	0	754	0 (0, 490)
Aetiology-confirmed, probable, and/or clinically suspected meningitis	0	754	0 (0, 490)
Suspected meningitis ruled out afterward	0	754	0 (0, 490)
Overall (N = 6897)
Aetiology-confirmed meningitis^a	2	4332	46 (6, 167)
Probable meningitis	0	4332	0 (0, 85)
Clinically suspected meningitis	2	4332	46 (6, 167)
Aetiology-confirmed, probable, and/or clinically suspected meningitis	4	4331	92 (25, 236)
Suspected meningitis ruled out afterward	1	4332	23 (1, 129)

According-to-protocol cohort, 5 to 17 months age-group
N, number of study participants at risk during a follow-up period of approximately 6 months after each dose of the virtual primary vaccination schedule censored at the next dose; n, number of cases reported during that follow-up period; CI: confidence interval; M: Months
^aOne case of aetiology-confirmed meningitis has been downgraded to probable meningitis after the interim analysis (see text for details)

ISSN: 1475-2875