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Fig. 17 | Malaria Journal

Fig. 17

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 17

Pathway 15 Human health: Potentially decreased human defence response to pathogen from altered levels of endogenous RNA or protein in the saliva dsxFCRISPRh transgenics could lead to increased disease in humans. The plausibility of this pathway stems from increasing evidence in the literature indicating that mosquito RNA injected from its saliva during biting might affect vector-host-parasite interactions [142,143,144]. The net effect of the population suppression gene drive could ultimately be to reduce this potential harm by reducing the density of mosquitoes including transgenic ones

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