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Fig. 30 | Malaria Journal

Fig. 30

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 30

Pathway 28 Human health: Potential toxicological effects of dsxFCRISPRh transgenics on NTOs could increase disease transmission in humans. Bioinformatic and literature evidence of any toxicity of DsRed and Cas9 will likely be more targeted towards outcomes in humans but nonetheless will contribute to weight of evidence supporting or refuting this pathway, whilst recognising that the mass of humans would greatly exceed that of any NTO. Defining the experimental conditions and choices of indicator species for chronic and acute studies will most likely involve discussion with national regulators, with reference to international regulatory guidance and best practice [26, 95]

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