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Fig. 33 | Malaria Journal

Fig. 33

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 33

Pathway 31 Animal health: Potential toxicity in livestock from dsxFCRISPRh transgenic proteins in saliva. This pathway is based on the potential harm that would be caused to an individual animal from exposure to the transgenic proteins. Manifestation of this potential harm would depend on (i) whether the transgenic proteins were toxic to livestock animals, and (ii) whether those proteins were expressed in the saliva of transgenics at doses known to be harmful to livestock animals. Toxicity profiles of transgenic proteins can be informed by bioinformatics analyses and inferences from toxicology studies in NTOs. The net effect of a population suppression gene drive would ultimately reduce this specific harm by reducing the density of the target species of mosquitoes, including transgenic ones

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