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Fig. 39 | Malaria Journal

Fig. 39

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 39

Pathway 37 Animal health: Potentially altered anatomy, or host-seeking behaviour, in dsxFCRISPRh transgenic could increase disease transmission in livestock. This pathway is about the efficiency of disease transmission, so any change in anatomical characteristics in the transgenics could increase the biting or probing rates or disease transmission rates. As dsxFCRISPRh transgenic mosquitoes have reported anatomical alterations [17], anatomical structures implicated in disease transmission, such as the cibarial armature, can be examined in transgenics [102]. The net effect of a population suppression gene drive would ultimately reduce the impact of this specific harm by reducing the density of mosquitoes, including transgenic ones. The components of vectorial capacity (V) that would be affected in this pathway are shown in red in the equation

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