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Fig. 40 | Malaria Journal

Fig. 40

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 40

Pathway 38 Animal health: Potentially altered anatomy in dsxFCRISPRh transgenic could lead it to vector livestock animal disease not previously-vectored by Anopheles gambiae. This pathway is about the efficiency of transmission, so any change in anatomical characteristics in the transgenics may increase the biting or probing rates or might increase the disease transmission rates. As dsxFCRISPRh transgenic mosquitoes have reported anatomical alterations [17], anatomical structures implicated in disease transmission, such as the cibarial armature, can be examined in transgenics [102]. The net effect of a population suppression gene drive would ultimately reduce the impact of this specific harm by reducing the density of mosquitoes, including transgenic ones. The components of vectorial capacity (V) that would be affected in this pathway are shown in red in the equation

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