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Fig. 41 | Malaria Journal

Fig. 41

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 41

Pathway 39 Animal health: Potentially altered physiology in dsxFCRISPRh transgenic could increase disease transmission in livestock. This pathway is about the efficiency of transmission, so any change in physiological characteristics in the transgenics, such as immune system function or capacity for co-infection or extrinsic incubation period [151], might increase the disease transmission rates of a given animal pathogen. The net effect of a population suppression gene drive would ultimately reduce the impact of this specific harm by reducing the density of mosquitoes, including transgenic ones. The components of vectorial capacity (V) that would be affected in this pathway are shown in red in the equation

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