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Fig. 44 | Malaria Journal

Fig. 44

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 44

Pathway 42 Animal health: Potentially broader tolerances for humidity, temperature, salinity, or desiccation in dsxFCRISPRh transgenics could lead to increased disease transmission in livestock. Were the transgenic to show a broadening of tolerance for environmental conditions, this could result in increased competition with existing species in its current geographic range, as well as new competition with new species in new range, in each case potentially increasing animal disease transmission. Transgenics with broadened tolerance for humidity and temperature might, for example, be expected to show extended survival into dry season compared to non-transgenic. The net effect of the population suppression gene drive should ultimately be to reduce this specific harm by reducing the density of mosquitoes including transgenic ones. The components of vectorial capacity (V) that would be affected in this pathway are shown in red in the equation

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