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Table 2 Controlled-release systems of mosquito repellent actives, polymeric material, mosquito repellent, and their preparation method

From: Mosquito‐repellent controlled‐release formulations for fighting infectious diseases

Mosquitoes

Product, active ingredient

and concentration

Protection (%)

Repellency time (h)

Manufacturer

References

Culex quinquefasciatus

Citriodiol® (30 %) based repellent (Mosiguard®)

100

3

Mosi-guard

[184]

C. quinquefasciatus

Citronella KAPS®

> 84

4

KAPS Mosquito Repellent Patch 12 s

[184]

C. quinquefasciatus

Citronella MozAway®

> 84

4

MozAway

[184]

C. quinquefasciatus

Citronella BioZ Natural®

> 81

4

BioZ Natural

[184]

Aedes aegypti

Citronellal

> 71

1

*

[192]

A. aegypti

Citronellol

> 77

1

*

[192]

A. aegypti

Geraniol

78

1

*

[192]

C. quinquefasciatus

Microencapsulated formulation of Essential oil (Citrus aurantifolia) 20 %

> 85

6

*

[184]

C. quinquefasciatus

Microencapsulated of Essential oil (C. aurantifolia) 15 %

> 84

6

*

[184]

C. quinquefasciatus

Microencapsulated of Essential oil (C. aurantifolia) 10 %

> 75

6

*

[184]

C. quinquefasciatus

Microencapsulated of Essential oil (C. aurantifolia) 5 %

> 63

6

*

[184]

C. quinquefasciatus

Non-encapsulated of Essential oil (C. aurantifolia 20 %

> 71

6

*

[184]

C. quinquefasciatus

Essential oil (Citrus grandis) 20 % microencapsuled

> 86

6

*

[184]

C. quinquefasciatus

Essential oil (C.s grandis) 15 % microencapsuled

> 83

6

*

[184]

C. quinquefasciatus

Essential oil (C. grandis) 10 % micrencapsulated

> 74

6

*

[184]

C. quinquefasciatus

Essential oil (C. grandis) 5 % micrencapsulated

> 65

6

*

[184]

C. quinquefasciatus

Non-encapsulated of Essential oil (C. grandis) 20 %

> 72

6

*

[184]

C. quinquefasciatus

Microencapsulated of Essential oil (Alpinias galanga) 20 %

> 88

6

*

[184]

C. quinquefasciatus

Microencapsulated of Essential oil (A.s galanga) 15 %

> 83

6

*

[184]

C. quinquefasciatus

Microencapsulated of Essential oil (A. galanga) 10 %

> 76

6

*

[184]

C. quinquefasciatus

Microencapsulated of Essential oil (A. galanga) 5 %

> 71

6

*

[184]

C. quinquefasciatus

Non-encapsulated of Essential oil (A. galanga) 20 %

> 73

6

*

[184]

Anopheles subpictus

Essential oil (Zingiber officinale Rosc. 5 mg/m2)

> 85

3

*

[193]

An. subpictus

Essential oil (Rosmarinus officinalis L.5 mg/m2)

> 68

3

*

[193]

An. subpictus

Essential oil (Cymbopogan citrates Stapf. 5 mg/m2)

> 74

3

*

[193]

An. subpictus

Essential oil from (Cinnamomum zeylanicum L.

5 mg/m2)

> 61

3

*

[193]

Anopheles darlingi

30 % PMD in ethanol

97

4

*

[194]

Aedes ochlerotatus taeniorhynchus

15 % PMD (derived by acid modification of Citronellal)

99

5

*

[194]

A. aegypti

Hazomalania voyronii fresh bark essential oil (EO) 100 %

> 82

0.5

*

[195]

C. quinquefasciatus

Boesenbergia rotunda oil 10 %

-

4

*

[196]

C. quinquefasciatus

Curcuma zedoaria oil 10 %

-

3

*

[196]

C. quinquefasciatus

Zingiber cassumunar oil 10 %

-

2

*

[196]

C. quinquefasciatus

L. petiolata oil 10 %

-

3

*

[196]

A. aegypti

Hazomalania voyronii fresh bark essential oil (EO) 50 %

> 78

0.5

*

[195]

C. quinquefasciatus

H. voyronii fresh bark essential oil (EO) 100 %

> 98

0.5

*

[195]

Aedes albopictus

Citronella oil 5 %

> 57

2

*

[197]

A. aegypti

Citrodiol into the ethylcellulose nanofibrous

100

816

*

[198]

Culex tritaeniorhynchus

Essential oil (Z. officinale Rosc. 5 mg/m2)

> 88

3

*

[193]

C. tritaeniorhynchus

Essential oil (R. officinalis L.5 mg/m2)

> 71

3

*

[193]

C. tritaeniorhynchus

Essential oil (C. citrates Stapf. 5 mg/m2)

> 79

3

*

[193]

C. tritaeniorhynchus

Essential oil from (C. zeylanicum L.

5 mg/m2)

> 64

3

*

[193]

An. darlingi

15 % DEET in Ethanol

85

4

*

[194]

A. ochlerotatus taeniorhynchus

15 % DEET in Ethanol

92

5

*

[194]

C. quinquefasciatus

20 % DEET

-

4

*

[196]

A. aegypti

20 % DEET

-

4

*

[196]

Anopheles gambiae and C. quinquefasciatus

DEET-treated nets (DEET-TN)

-

1008

*

[199]

A. albopictus

Skinsations® Spray-DEET 7 %

-

5

Spectrum Division of United Industries Corporation

[200]

A. albopictus

Off! Spray DEET 15 %

-

> 7

S.C. Johnson & Son Inc.

[200]

A. aegypti

DEET 20 %

> 82

5

*

[201]

Aedes communis

DEET (The amount was not specified)

98

4

*

[202]

A. communis

DEET (The amount was not specified)

74

6

*

[202]

A. communis

DEET (The amount was not specified)

56

8

*

[202]

A. communis

DEET + AI3-37220 (The amount was not specified)

98

4

*

[202]

A. communis

DEET + AI3-37220 (The amount was not specified)

95

6

*

[202]

A. communis

DEET + AI3-37220 (The amount was not specified)

76

8

*

[202]

A. aegypti

OFF! Deep Woods-DEET 23.8 %

-

> 5

S.C. Johnson & Son Inc.

[203]

A. aegypti

Sawyer Controlled Release®-DEET 20 %

-

> 3

Sawyer

[203]

A. aegypti

OFF! Skintastic-DEET 6.65 %

-

> 1

S.C. Johnson & Son Inc.

[203]

A. aegypti

OFF! Skintastic for Kids-DEET 4.75 %

-

> 1

S.C. Johnson & Son Inc.

[203]

A. aegypti

DEET 25 %

100

6

*

[204]

A. aegypti

DEET 25 % + Vanillin 5 %

100

6

*

[204]

A. aegypti

DEET 20 % in ethanol

100

7

*

[204]

A. aegypti

DEET 20 % in ethanol

100

8

*

[205]

Aedes vigilax

DEET 34.6 % Army repellent personal

> 95

5

*

[206]

A. albopictus

DEET 10 %

100

4

*

[207]

A. albopictus

DEET 10 %

> 88

6

*

[207]

A. albopictus

DEET 10 %

> 77

8

*

[207]

A. aegypti

DEET 12 % Cream

> 96

> 6

*

[208]

Anopheles spp.

DEET 20 %

> 88

4

*

[206]

Anopheles spp.

DEET 20 %

> 74

5

*

[206]

An. gambiae

DEET 30 %

> 88

7

*

[209]

Anopheles stephensi

DEET 12 % Cream

100

11

*

[208]

Anopheles culicifacies

DEET 12 % Cream

100

11

*

[208]

Anopheles annularis

DEET 12 % Cream

100

11

*

[208]

An. subpictus

DEET 12 % Cream

100

11

*

[208]

A. albopictus

Insectan Spray DEET 24 %

> 90

6

*

[210]

Anopheles arabiensis

Socks – DEET 20 %

> 90

3360

*

[13]

C. quinquefasciatus

Microencapsulated DEET 20 %

98

6

*

[184]

C. quinquefasciatus

Microencapsulated DEET 15 %

95

6

*

[184]

C. quinquefasciatus

Microencapsulated DEET 10 %

85

6

*

[184]

C. quinquefasciatus

Microencapsulated DEET 5 %

83

6

*

[184]

C. quinquefasciatus

Non-Encapsulated DEET 20 %

91

6

*

[184]

C. quinquefasciatus

DEET 1 %

90

-

*

[211]

A. aegypti

DEET 1 %

77

-

*

[211]

A. aegypti

OFF Family – DEET < 10 %

-

2

S.C. Johnson & Son Inc.

[9]

A. aegypti

Repelex – DEET < 10 %

-

2

US CHEMCO Supply & Service

[9]

A. aegypti

Mosquitoff – DEET 10 %

-

> 2

S.C. Johnson & Son Inc.

[9]

A. aegypti

SBP – Icaridin 15 %

-

5

Sawyer Products

[9]

A. aegypti

OFF kids – DEET < 10 %

-

2

S.C. Johnson & Son Inc.

[9]

A. aegypti

Muriel – DEET < 10 %

-

2

 

[9]

A. aegypti

Kor Yor 15® DEET

-

> 7

S.C. Johnson & Son Inc.

[212]

C. quinquefasciatus

Kor Yor 15® DEET

-

> 7

S.C. Johnson & Son Inc.

[212]

An. arabiensis

LLDPE strands-DEET 20 %

79

2016

*

[14]

An. arabiensis

LLDPE strands-DEET 30 %

78

2016

*

[14]

An. arabiensis

EVA strands-Icaridin 20 %

85

2016

*

[14]

An. arabiensis

EVA strands-Icaridin 30 %

82

2016

*

[14]

A. aegypti

DEET 10 %

> 83

2

*

[195]

C. quinquefasciatus

DEET 10 %

100

2

*

[195]

A. albopictus

DEET 24 %

> 90

6

*

[197]

A. aegypti

Exposis – Icaridin 25 %

-

10

Laboratório Osler do Brasil

[9]

A. albopictus

IR3535 20 % in ethanol solution

-

5

*

[205]

A. aegypti

IR3535 20 % in ethanol solution

-

> 9

*

[205]

A. albopictus

IR3535 10 %

-

> 7

*

[205]

Anopheles dirus

IR3535 10 %

-

8

*

[205]

A. aegypti

IR3535 10 %

-

> 6

*

[205]

C. quinquefasciatus

IR3535 10 %

-

8

*

[205]

An. dirus

IR3535 20 % in ethanol solution

-

> 3

*

[205]

C. quinquefasciatus

IR3535 20 % in ethanol solution

-

> 13

*

[205]

C. tritaeniorhynchus

IR3535 20 % in ethanol solution

-

> 14

*

[205]

A. aegypti

IR3535 10 % Spray®

95

6

*

[205]

A. aegypti

IR3535 10 % Spray®

90

6

*

[213]

A. aegypti

IR3535 10 % Spray®

85

7

*

[213]

A. aegypti

IR3535 15 % Spray®

95

6

*

[213]

A. aegypti

IR3535 15 % Spray®

90

6

*

[213]

A. aegypti

IR3535 15 % Spray®

85

6

*

[213]

A. aegypti

IR3535 10 % Lotion®

95

4

*

[213]

A. aegypti

IR3535 10 % Lotion®

90

5

*

[213]

A. aegypti

IR3535 10 % Lotion®

85

6

*

[213]

A. aegypti

IR3535 15 % Lotion®

95

6

*

[213]

A. aegypti

IR3535 15 % Lotion®

90

6

*

[213]

A. aegypti

IR3535 15 % Lotion®

85

6

*

[213]

A. aegypti

IR3535 20 % Spray®

95

6

*

[213]

An. arabiensis

IR3535 100 %

62

4

*

[10]

An. arabiensis

Blend IR3535 75 mol%-nonanoic

100

4

*

[10]

A. aegypti

IR3535 20 % Spray®

90

7

*

[213]

A. aegypti

IR3535 20 % Spray®

85

7

*

[213]

Aedes spp. Culex spp.

IR3535 20 % Pump spray

85

> 7

*

[214]

Anopheles spp.

IR3535 20 % Pump spray

-

> 7

*

[214]

A. albopictus

Icaridin 10 % Autan® spray

-

> 5

*

[200]

A. aegypti

Icaridin 10 % Lotion

95

6

*

[213]

A. aegypti

Icaridin 10 % Lotion

90

7

*

[213]

A. aegypti

Icaridin 10 % Lotion

85

8

*

[213]

A. aegypti

Icaridin 20 % Spray

95

6

*

[213]

A.aegypti

Icaridin 20 % Spray

90

7

*

[213]

A. aegypti

Icaridin 20 % Spray

85

9

*

[213]

An. stephensi

Bayrepel 20 % in complex solvent

100

8

*

[215]

C. quinquefasciatus

Bayrepel 20 % in complex solvent

100

8

*

[215]

Culex annulirostris

Icaridin® 19.2 % in ethanol Bayrepel Army®

≥ 99

5

*

[206]

C. annulirostris

Icaridin® 19.2 % in ethanol Bayrepel Army®

85

6

*

[206]

Anopheles spp.

Icaridin 19.2 % in ethanol Bayrepel Army®

>86

6

*

[206]

Anopheles spp.

Icaridin 19.2 % in ethanol Bayrepel Army®

>71

7

*

[206]

An. arabiensis

LLDPE strands-Icaridin 20 %

79

2016

*

[14]

An. arabiensis

LLDPE strands-Icaridin 30 %

98

2016

*

[14]

An. arabiensis

EVA strands-Icaridin 20 %

91

2016

*

[14]

An. arabiensis

EVA strands-Icaridin 30 %

88

2016

*

[14]

A. albopictus

Butyl anthranilate (BA) 0.1 %

> 53

-

*

[216]

A. albopictus

Ethyl anthranilate (EA) 0.1 %

> 38

-

*

[216]

A. aegypti

Ethyl anthranilate (EA) 10 %

100

-

*

[217]

A. aegypti

Ethyl anthranilate (EA) 5 %

90

-

*

[217]

A. aegypti

Ethyl anthranilate (EA) 2 %

78

-

*

[217]

An. stephensi

Ethyl anthranilate (EA) 10 %

96

-

*

[217]

An. stephensi

Ethyl anthranilate (EA) 5 %

80

-

*

[217]

An. stephensi

Ethyl anthranilate (EA) 2 %

68

-

*

[217]

C. quinquefasciatus

Ethyl anthranilate (EA) 10 %

88

-

*

[217]

C. quinquefasciatus

Ethyl anthranilate (EA) 5 %

82

-

*

[217]

C. quinquefasciatus

Ethyl anthranilate (EA) 2 %

64

-

*

[217]

  1. aPoloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG)